芝麻油与维生素E联合使用可能改善代谢综合征患者的心血管代谢危险因素：一项随机临床试验。
Sesame oil and vitamin E co-administration may improve cardiometabolic risk factors in patients with metabolic syndrome: a randomized clinical trial.
作者信息
Farajbakhsh Ali, Mazloomi Seyed Mohammad, Mazidi Mohsen, Rezaie Peyman, Akbarzadeh Marzieh, Ahmad Saeedeh Poor, Ferns G A, Ofori-Asenso Richard, Babajafari Siavash
机构信息
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Food Hygiene and Quality Control, School and Research Center of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Eur J Clin Nutr. 2019 Oct;73(10):1403-1411. doi: 10.1038/s41430-019-0438-5. Epub 2019 May 14.
OBJECTIVES
Metabolic syndrome (MetS) represents a clustering of metabolic abnormalities that are associated with an increased risk of type 2 diabetes and cardiovascular disease. We aimed to evaluate the effects of sesame oil enriched with vitamin E (vit E), sesame oil alone and sunflower oil on lipid profile, fasting blood glucose (FBG), malondialdehyde (MDA), high-sensitivity C-reactive protein (Hs-CRP), homeostatic model assessment (HOMA-IR), and blood pressure (BP) in patients with MetS.
SUBJECTS
Overall, 75 individuals with MetS (aged 30-70 years) participated in this randomized, single-blind controlled trial. Patients were randomly allocated to: (1) Group A (n = 25): sesame oil (30 ml/day) enriched with vit E (400 mg/day), (2) Group B (n = 25): sesame oil (30 ml/day), (3) Group C (n = 25): sunflower oil (30 ml/day). Anthropometric data, dietary intake, blood pressure, and biochemical markers, including fasting serum lipids, FBG, serum insulin, MDA, and hs-CRP were measured at baseline and at week 8.
RESULTS
In individuals in the sesame oil enriched with vit E group (Group A), there were significant reductions in serum total cholesterol (TC), triglycerides (TG), FBG, HOMA-IR, MDA, hs-CRP, high-density lipoprotein (HDL-C) systolic and diastolic BP (for all the comparison p < 0.02). Similarly, in Group B (taking sesame oil alone), TC, TG, FBG, HOMA-IR, MDA, systolic and diastolic BP were significantly improved (for all the comparison p < 0.025), while there were no significant changes in serum HDL (baseline = 35.9 ± 7.2 mg/dL vs. 36.4 ± 6.2 mg/dL, p = 0.432) and hs-CRP (baseline = 4.38 ± 1.34 mg/dL vs. week 8 = 3.96 ± 1.7 mg/dL, p = 0.057) in second group. No significant changes in any of the studied clinical and anthropometric data were found in Group C (on sunflower oil).
CONCLUSION
Sesame oil (±vit E) was shown to beneficially affect several cardiometabolic indices (including lipids, FBG, BP, HOMA-IR, and MDA) in patients with MetS.
目的
代谢综合征（MetS）表现为一系列代谢异常的聚集，与2型糖尿病和心血管疾病风险增加相关。我们旨在评估富含维生素E（vit E）的芝麻油、单纯芝麻油和葵花籽油对代谢综合征患者血脂谱、空腹血糖（FBG）、丙二醛（MDA）、高敏C反应蛋白（Hs-CRP）、稳态模型评估（HOMA-IR）和血压（BP）的影响。
受试者
总共75名患有代谢综合征的个体（年龄30 - 70岁）参与了这项随机、单盲对照试验。患者被随机分配到：（1）A组（n = 25）：富含vit E（400毫克/天）的芝麻油（30毫升/天），（2）B组（n = 25）：芝麻油（30毫升/天），（3）C组（n = 25）：葵花籽油（30毫升/天）。在基线和第8周测量人体测量数据、饮食摄入量、血压和生化指标，包括空腹血脂、FBG、血清胰岛素、MDA和Hs-CRP。
结果
在富含vit E的芝麻油组（A组）个体中，血清总胆固醇（TC）、甘油三酯（TG）、FBG、HOMA-IR、MDA、Hs-CRP、高密度脂蛋白（HDL-C）、收缩压和舒张压均显著降低（所有比较p < 0.02）。同样，在B组（仅服用芝麻油）中，TC, TG, FBG, HOMA-IR, MDA, 收缩压和舒张压均显著改善（所有比较p < 0.025）, 而第二组血清HDL（基线 = 35.9 ± 7.2毫克/分升vs. 36.4 ± 6.2毫克/分升, p = 0.432）和Hs-CRP（基线 = 4.38 ± 1.34毫克/分升vs. 第8周 = 3.96 ± 1.7毫克/分升, p = 0.057）无显著变化。C组（食用葵花籽油）的任何研究临床和人体测量数据均无显著变化。
结论
芝麻油（含或不含vit E）对代谢综合征患者的几种心脏代谢指标（包括血脂、FBG、BP、HOMA-IR和MDA）有有益影响。
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