Department of Medical Insurance, School of Health Services Management, Anhui Medical University, Hefei, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Andrologia. 2019 Aug;51(7):e13304. doi: 10.1111/and.13304. Epub 2019 May 15.
Over the past decades, there is an increasing number of association studies of telomere length (TL) and the risk and recurrence of prostate cancer (PCa), but the results are inconsistent. Hence, we identify the relevant studies published in English on or before 10 January 2019 conducting a literature review in the electronic databases including PubMed, EMBASE and Cochrane Library. Twelve studies (with 19 data sets) were included in this meta-analysis, five of which were associated with risk assessment, six of which reported recurrence of PCa and one of which included them. Our meta-analysis demonstrated a positive association of shorter telomeres in patients with PCa, but without statistical significance (OR, 1.23; 95% CI: 0.91-1.66). Shorter telomeres in stroma (OR, 2.40; 95% CI: 1.61-3.56) and epithelium (OR, 1.70; 95% CI: 1.33-2.16) were positively correlated with PCa, but in leucocyte (OR, 0.81; 95% CI: 0.73-0.91) had negative association with PCa. Furthermore, two studies combined yielded a pooled OR of 2.87 (95% CI: 1.22-6.76) for the association between shorter TL and metastasis. These results are novel and give further strength to formulate eligible individualising treatment and surveillance strategies.
在过去的几十年中，越来越多的研究探讨了端粒长度（TL）与前列腺癌（PCa）风险和复发的关系，但结果并不一致。因此，我们检索了截至 2019 年 1 月 10 日发表在英文文献中的相关研究，检索数据库包括 PubMed、EMBASE 和 Cochrane Library。本荟萃分析共纳入了 12 项研究（涉及 19 个数据集），其中 5 项研究与风险评估相关，6 项研究报道了 PCa 的复发情况，1 项研究同时包含这两方面的内容。我们的荟萃分析表明，PCa 患者端粒较短与疾病发生呈正相关，但无统计学意义（OR，1.23；95%CI：0.91-1.66）。肿瘤基质（OR，2.40；95%CI：1.61-3.56）和上皮（OR，1.70；95%CI：1.33-2.16）中端粒较短与 PCa 呈正相关，而白细胞（OR，0.81；95%CI：0.73-0.91）中端粒较短与 PCa 呈负相关。此外，两项研究的合并结果显示，端粒较短与转移之间存在关联，合并 OR 为 2.87（95%CI：1.22-6.76）。这些结果是新颖的，为制定合适的个体化治疗和监测策略提供了进一步的依据。
