Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, New York, USA.
Department of Psychiatry and Pharmacology, University of Toronto, Toronto, Ontario, Canada.
J Clin Psychiatry. 2019 Apr 30;80(3):lu18052ah1. doi: 10.4088/JCP.lu18052ah1.
Although the sedative and extrapyramidal side effects associated with first-generation antipsychotics are well known, some second-generation antipsychotics are also associated with substantial sedation and activation effects. In this Academic Highlights article, 4 experts on depression from the fields of psychiatry and primary care take a closer look at activation and sedation effects of atypical antipsychotics in patients with MDD. They examine the likelihood of each agent to cause these effects; the impact of these effects on patient functioning, quality of life, and treatment adherence; and the question of whether leveraging activation and sedation to address acute symptoms is ever advisable.
尽管第一代抗精神病药物的镇静和锥体外系副作用是众所周知的，但一些第二代抗精神病药物也与大量的镇静和激活作用有关。在这篇学术亮点文章中，来自精神病学和初级保健领域的 4 位抑郁症专家更深入地研究了非典型抗精神病药物在 MDD 患者中的激活和镇静作用。他们检查了每个药物引起这些作用的可能性；这些作用对患者功能、生活质量和治疗依从性的影响；以及利用激活和镇静作用来治疗急性症状是否可取的问题。
