Rauber Mariana R, Pilger Diogo A, Cecconello Daiane K, Falcetta Frederico S, Marcondes Natália A, Faulhaber Gustavo A M
Programa de Pós-Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2400, 2° andar, 90035-003 Porto Alegre, RS, Brazil.
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752, 90610-000 Porto Alegre, RS, Brazil.
An Acad Bras Cienc. 2019 May 13;91(2):e20180286. doi: 10.1590/0001-3765201920180286.
Investigation of hyperferritinemia in metabolic syndrome patients represents a diagnostic challenge, but it is essential for the identification of individuals with iron overload. Hepcidin negatively regulates iron absorption and release. An increase in hepcidin occurs when iron levels are sufficient or in inflammatory states, conditions often associated with hyperferritinemia. Hemochromatosis causes hyperferritinemia due to iron overload, but frequently has low hepcidin levels. Our aim was to evaluate biochemical and molecular parameters related to iron metabolism in patients with metabolic syndrome. We evaluated 94 patients with metabolic syndrome according to the International Diabetes Federation criteria in a cross-sectional study. Anthropometric data and diagnostic criteria for metabolic syndrome, iron dosage, ferritin, transferrin saturation, hepcidin, and the C282Y and H63D mutations in the HFE hemochromatosis gene were evaluated. Prevalence of hyperferritinemia in the study population was 27.7% and was higher in males (46.2%) than in females (14.5%). Increase in transferrin saturation correlated with mutations in the hemochromatosis gene. Hyperferritinemia was associated to transferrin saturation and hepcidin after logistic regression analysis. In conclusion, hyperferritinemia is a frequent finding in metabolic syndrome patients, most frequently in men; and hepcidin assessment can be useful for the investigation of ferritin increase in those subjects.
对代谢综合征患者高铁蛋白血症的研究是一项诊断挑战，但对于识别铁过载个体至关重要。铁调素对铁的吸收和释放起负调节作用。当铁水平充足或处于炎症状态时，铁调素会增加，而这些情况通常与高铁蛋白血症相关。血色素沉着症由于铁过载导致高铁蛋白血症，但铁调素水平常常较低。我们的目的是评估代谢综合征患者与铁代谢相关的生化和分子参数。在一项横断面研究中，我们根据国际糖尿病联盟标准评估了94例代谢综合征患者。评估了人体测量数据和代谢综合征的诊断标准、铁含量测定、铁蛋白、转铁蛋白饱和度、铁调素以及血色素沉着症基因HFE中的C282Y和H63D突变。研究人群中高铁蛋白血症的患病率为27.7%，男性（46.2%）高于女性（14.5%）。转铁蛋白饱和度的增加与血色素沉着症基因突变相关。经逻辑回归分析，高铁蛋白血症与转铁蛋白饱和度和铁调素相关。总之，高铁蛋白血症在代谢综合征患者中很常见，在男性中最为常见；铁调素评估对于调查这些受试者中铁蛋白增加可能有用。
