Vargiu Michela, Favero Lucilla, Menichetti Andrea, Di Bussolo Valeria, Marchetti Fabio, Pescitelli Gennaro, Di Pietro Sebastiano, Pineschi Mauro
Dipartimento di Farmacia, Sede di Chimica Bioorganica e Biofarmacia, Università di Pisa, Pisa, Italy.
Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Pisa, Italy.
Chirality. 2019 Jul;31(7):522-533. doi: 10.1002/chir.23077. Epub 2019 May 15.
The direct heterofunctionalization of acyclic α,β-unsaturated aldehydes with N-acylquinolinium ions contemplating the formation of two stereocentres is studied using dienamine catalysis. This work gives some new experimental insights on the remote stereocontrol in dienamine catalysis using unbiased aliphatic systems and large electrophiles, pointing to a (Z)-preference of the reactive configuration of the second double bond.
利用烯胺催化研究了无环α,β-不饱和醛与N-酰基喹啉离子的直接杂官能化反应，该反应涉及两个立体中心的形成。这项工作为使用无偏脂肪族体系和大亲电试剂的烯胺催化中的远程立体控制提供了一些新的实验见解，表明第二个双键的反应构型具有(Z)-偏好性。
