[环氧乙烷及其反应产物2-氯乙醇、2-溴乙醇、乙二醇和二甘醇的致癌活性。III. 乙二醇和二甘醇致癌作用的研究]

[Carcinogenic activity of ethylene oxide and its reaction products 2-chloroethanol, 2-bromoethanol, ethylene glycol and diethylene glycol. III. Research on ethylene glycol and diethylene glycol for carcinogenic effects].

作者信息

Dunkelberg H

出版信息

Zentralbl Bakteriol Mikrobiol Hyg B Umwelthyg Krankenhaushyg Arbeitshyg Prav Med. 1987 Mar;183(4):358-65.

Abstract

Ethylene glycol and diethylene glycol were each administered once weekly subcutaneously to groups of 100 female NMRI mice at 3 dosages (30; 10 und 3 mg single dose per mouse). Tricaprylin was used as solvent. The mean total dosage per mouse was 2110.5; 707.0 and 196.2 mg for ethylene glycol and 2029.8; 671.7 and 213.3 mg for diethylene glycol. Neither ethylene glycol nor diethylene glycol induced tumors at the injection site or away from the point of administration.

摘要

将乙二醇和二甘醇分别以3种剂量（每只小鼠单次剂量为30、10和3毫克）每周皮下注射一次，每组100只雌性NMRI小鼠。使用三辛酸甘油酯作为溶剂。每只小鼠的乙二醇平均总剂量分别为2110.5、707.0和196.2毫克，二甘醇的平均总剂量分别为2029.8、671.7和213.3毫克。乙二醇和二甘醇均未在注射部位或给药点以外诱发肿瘤。

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