Dempsey D T, Mullen J L
Am J Clin Nutr. 1987 Jun;45(6):1526-32. doi: 10.1093/ajcn/45.6.1526.
Nutritional repletion with glucose-based total parenteral nutrition (TPN), mixed-substrate (58% lipid, 42% glucose) TPN, and mixed-substrate total enteral nutrition (TEN) was studied in four adult male chair-adapted primates using a crossover design. After 10 d nutritional depletion animals were repleted for 10 d with one of three isocaloric isonitrogenous diets. TPN Diets I and II were identical except that I provided all nonprotein calories as glucose while II provided 58% nonprotein calories as lipid and 42% as glucose. Animals were randomized to I or II as their first repletion treatment. The 20-d depletion-repletion cycle was repeated with the other TPN diet after a 30-d rest period of caged free-feeding. After another 30-d rest period, animals underwent a third 10-d depletion and were repleted with 10 d of TEN (Diet III, identical to II in composition). The three diets resulted in similar weight gain, positive nitrogen balance and fluid balance, and increase in total iron-binding capacity.
采用交叉设计，在四只成年雄性适应轮椅的灵长类动物中研究了基于葡萄糖的全胃肠外营养（TPN）、混合底物（58%脂质，42%葡萄糖）TPN和混合底物全肠内营养（TEN）的营养补充情况。在10天的营养耗竭期后，用三种等热量等氮量饮食之一对动物进行10天的营养补充。TPN饮食I和II除了I提供所有非蛋白热量为葡萄糖，而II提供58%非蛋白热量为脂质和42%为葡萄糖外，其他相同。动物被随机分为I或II作为其首次补充治疗。在30天的笼养自由进食休息期后，用另一种TPN饮食重复20天的耗竭-补充周期。在另一个30天的休息期后，动物进行第三次10天的耗竭，并补充10天的TEN（饮食III，成分与II相同）。三种饮食导致相似的体重增加、正氮平衡和液体平衡，以及总铁结合能力增加。
