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在动物实验中使用新剂型增强对癌性腹膜炎的化疗疗效。

Enhanced chemotherapeutic efficacy on carcinomatous peritonitis using a new dosage form in animal experiments.

作者信息

Hagiwara A, Takahashi T, Lee R, Ueda T, Takeda M, Itoh T

出版信息

Anticancer Res. 1987 Mar-Apr;7(2):167-70.

PMID:3109313
Abstract

A new dosage form, comprising Mitomycin C adsorbed on activated carbon particles (MMC-CH) was studied for its local therapeutic effects on carcinomatous peritonitis. After intraperitoneal transplantation of 10(7) cells of Yoshida sarcoma, drug treatment was given on day 2. The ED50 value on ascites was determined with Litchfield-Wilcoxon's method on day 6. The therapeutic index (LD50/ED50) on ascites in MMC-CH treatment was 3.09 times higher than that in Mitomycin C solution treatment.

摘要

研究了一种新剂型，即丝裂霉素C吸附在活性炭颗粒上的制剂（MMC-CH）对癌性腹膜炎的局部治疗效果。在腹腔移植10⁷个吉田肉瘤细胞后，于第2天给予药物治疗。在第6天用Litchfield-Wilcoxon法测定腹水的半数有效剂量（ED50）值。MMC-CH治疗组腹水的治疗指数（LD50/ED50）比丝裂霉素C溶液治疗组高3.09倍。

相似文献

1
Enhanced chemotherapeutic efficacy on carcinomatous peritonitis using a new dosage form in animal experiments.在动物实验中使用新剂型增强对癌性腹膜炎的化疗疗效。
Anticancer Res. 1987 Mar-Apr;7(2):167-70.
2
Toxicity and pathological effects of a new dosage form of mitomycin C for carcinomatous peritonitis.丝裂霉素C新剂型对癌性腹膜炎的毒性及病理影响
Anticancer Res. 1987 Jan-Feb;7(1):105-8.
3
Enhanced anticancer efficacy by use of mitomycin C adsorbed on small activated carbon particles in mice.在小鼠中使用吸附在小活性炭颗粒上的丝裂霉素C提高抗癌疗效。
Jpn J Cancer Res. 1987 Apr;78(4):405-8.
4
[Targeting chemotherapy with activated carbon particles adsorbing anti-cancer drugs].[用吸附抗癌药物的活性炭颗粒靶向化疗]
Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-1):1038-42.
5
Intraoperative chemotherapy with carbon particles adsorbing mitomycin C for gastric cancer with peritoneal dissemination in rabbits.兔腹膜播散性胃癌术中应用吸附丝裂霉素C的碳粒子进行化疗
Surgery. 1988 Nov;104(5):874-81.
6
Affinity of intraperitoneally injected activated carbon particles adsorbing mitomycin C to tumor surface of Yoshida sarcoma.腹腔注射吸附丝裂霉素C的活性炭颗粒对吉田肉瘤肿瘤表面的亲和力。
Anticancer Drug Des. 1990 Nov;5(4):359-69.
7
[Intraoperative chemotherapy with intraperitoneal activated carbon particles adsorbing mitomycin C against peritoneal dissemination of gastric cancer].[术中腹腔内注入活性炭微粒吸附丝裂霉素C治疗胃癌腹膜转移]
Gan To Kagaku Ryoho. 1989 Aug;16(8 Pt 2):2748-51.
8
[Intraabdominal administration of MMC adsorbed on activated carbon for management of carcinomatous peritonitis].[活性炭吸附丝裂霉素腹腔内给药治疗癌性腹膜炎]
Gan To Kagaku Ryoho. 1984 Aug;11(8):1550-6.
9
Selective delivery of high levels of mitomycin C to peritoneal carcinomatosis using a new dosage form.使用一种新剂型将高剂量丝裂霉素C选择性递送至腹膜癌病处。
Anticancer Res. 1986 Sep-Oct;6(5):1161-4.
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Animal experiments as a model for clinical trials of a new dosage form of mitomycin C for peritoneal carcinomatosis.以动物实验作为丝裂霉素C新剂型用于腹膜癌病临床试验的模型。
In Vivo. 1987 Jan-Feb;1(1):43-6.

引用本文的文献

1
Prophylaxis and treatment of peritoneal carcinomatosis: intraperitoneal chemotherapy with mitomycin C bound to activated carbon particles.腹膜癌病的预防和治疗：丝裂霉素C与活性炭颗粒结合的腹腔内化疗。
World J Surg. 1995 Jul-Aug;19(4):565-9. doi: 10.1007/BF00294724.