[重组人β干扰素与γ干扰素联合作用于裸鼠癌性腹膜炎实验模型的研究]

[Combined effect of human recombinant interferon-beta and interferon-gamma against an experimental model of peritonitis carcinomatosa in nude mice].

作者信息

Kondo H, Tanaka N, Naomoto Y, Orita K

出版信息

Gan To Kagaku Ryoho. 1987 Jun;14(6 Pt 1):1836-40.

Abstract

The development of useful therapy for the peritonitis carcinomatosa of gastrointestinal cancer is an important theme in cancer therapy. We developed an experimental model of peritonitis carcinomatosa in nude mice transplanted intraperitoneally human colon cancer cells. In this study, we investigated combined effect of human recombinant interferon-beta (rIFN-beta) and recombinant interferon-gamma (rIFN-gamma) in vivo using this model. The result indicate that each rIFN-beta and rIFN-gamma showed a significant prolonged survival compared with the control group (mean survival days: 41.8 +/- 5.0 days). Furthermore, combined administration of rIFN-beta and rIFN-gamma showed a marked prolonged survival (mean survival days: 114.0 +/- 7.4 days) compared with rIFN-beta or rIFN-gamma alone. These results suggest that a combined treatment of rIFN-beta and rIFN-gamma may be useful against peritonitis carcinomatosa of gastrointestinal cancer.

摘要

开发针对胃肠道癌腹膜癌的有效治疗方法是癌症治疗中的一个重要课题。我们建立了一个在裸鼠体内腹腔移植人结肠癌细胞的腹膜癌实验模型。在本研究中，我们使用该模型研究了人重组干扰素-β（rIFN-β）和重组干扰素-γ（rIFN-γ）在体内的联合作用。结果表明，与对照组相比，rIFN-β和rIFN-γ各自均显著延长了生存期（平均生存期：41.8±5.0天）。此外，与单独使用rIFN-β或rIFN-γ相比，联合使用rIFN-β和rIFN-γ显著延长了生存期（平均生存期：114.0±7.4天）。这些结果表明，rIFN-β和rIFN-γ联合治疗可能对胃肠道癌腹膜癌有效。

相似文献

1

[Combined effect of human recombinant interferon-beta and interferon-gamma against an experimental model of peritonitis carcinomatosa in nude mice].[重组人β干扰素与γ干扰素联合作用于裸鼠癌性腹膜炎实验模型的研究]

Gan To Kagaku Ryoho. 1987 Jun;14(6 Pt 1):1836-40.

2

Antitumor effect of recombinant human interferon-beta and interferon-gamma in combination against human colon cancer cell line in vitro and in nude mice.重组人β干扰素和γ干扰素联合应用对人结肠癌细胞系的体外及裸鼠体内抗肿瘤作用

Jpn J Cancer Res. 1987 Nov;78(11):1258-65.

3

[Synergistic effect of recombinant human interferon-beta and -gamma on human colon cancer transplanted into nude mice].[重组人β干扰素和γ干扰素对移植到裸鼠体内的人结肠癌的协同作用]

Gan To Kagaku Ryoho. 1986 Oct;13(11):3155-60.

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Antitumor effect of human recombinant interferon-gamma alone and in combination with adriamycin on a human colon cancer cell line (RPMI 4788) in vitro and in nude mice.

Jpn J Cancer Res. 1987 Dec;78(12):1400-8.

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Antitumor effect of combined intraperitoneal administration of human recombinant interferon-beta and interferon-gamma against intraabdominal carcinomatosis in nude mice.人重组β干扰素与γ干扰素联合腹腔给药对裸鼠腹腔内癌转移的抗肿瘤作用

Acta Med Okayama. 1988 Apr;42(2):69-75. doi: 10.18926/AMO/31012.

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Effects of interleukin-2 and interferon-beta treatment on lymphocytes in various tumor-bearing mice.白细胞介素-2和β-干扰素治疗对各种荷瘤小鼠淋巴细胞的影响。

J Biol Regul Homeost Agents. 1989 Jul-Sep;3(3):108-11.

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[Assessment of the combined effects of mitomycin C with alpha-interferon or gamma-interferon by the clonogenic assay technique].[采用克隆形成试验技术评估丝裂霉素C与α-干扰素或γ-干扰素的联合效应]

Gan To Kagaku Ryoho. 1985 May;12(5):1056-62.

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