[采用克隆形成试验技术评估丝裂霉素C与α-干扰素或γ-干扰素的联合效应]
[Assessment of the combined effects of mitomycin C with alpha-interferon or gamma-interferon by the clonogenic assay technique].
作者信息
Hirabayshi N, Nishiyama M, Yamaguchi M, Yoshinaka K, Nosoh Y, Toge T, Niimoto M, Hattori T, Ohkita T
出版信息
Gan To Kagaku Ryoho. 1985 May;12(5):1056-62.
The combined effects of Mitomycin C (MMC) with alpha-interferon (HLBI) or gamma-interferon (TRP-2), which have become attractive drugs for use as Biological Response Modifiers, were investigated using the human tumor clonogenic assay technique. Tumors in this study were five human tumor xenografts serially transplanted into nude mice (three gastric cancer, two colon cancer). When the survival fraction occurring with the combination was smaller than that obtained by multiplication of the survival fractions occurring with either drug alone, the combined effect was considered to be synergism. Four out of five xenografts (three gastric cancer, one colon cancer) showed synergistic effects for the combination of MMC with alpha-interferon. Although two gastric cancer xenografts showed synergism for the combination of MMC with gamma-interferon, antagonistic effects were observed in one gastric cancer and one colon cancer xenograft.
丝裂霉素C（MMC）与α-干扰素（HLBI）或γ-干扰素（TRP-2）联合使用，这两种药物作为生物反应调节剂已成为有吸引力的用药选择，本研究采用人肿瘤克隆形成试验技术对其联合效应进行了研究。本研究中的肿瘤是五种连续移植到裸鼠体内的人肿瘤异种移植瘤（三种胃癌、两种结肠癌）。当联合用药时的存活分数小于单独使用任一药物时存活分数的乘积时，联合效应被认为是协同作用。五种异种移植瘤中有四种（三种胃癌、一种结肠癌）显示MMC与α-干扰素联合具有协同效应。虽然两种胃癌异种移植瘤显示MMC与γ-干扰素联合具有协同作用，但在一种胃癌和一种结肠癌异种移植瘤中观察到拮抗作用。
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