The Center of Gerontology and Geriatrics, West China Hospital ,Sichuan Universtiy, , , ChinaThe Center of Gerontology and Geriatrics, West China Hospital ,Sichuan Universtiy, China.
J Rehabil Med. 2019 Jul 8;51(7):473-478. doi: 10.2340/16501977-2560.
To investigate the effect of different levels of exercise on telomere length.
CINAHL, SPORTDiscus (EBSCO), OVID (Medline) and EMBASE databases were searched for eligible studies. Methodological quality was evaluated using the Newcastle-Ottawa Scale, and heterogeneity among the studies was assessed using the I-squared test. When heterogeneity among studies was high (I2 > 50%), a random-effects model was used (Review Manager version 5, Cochrane Collaboration, Copenhagen, Denmark); otherwise, a fixed-effects model was used.
Eleven eligible studies involving 19,292 participants were included in this meta-analysis. Longer telomere length was associated with physically active individuals, with a mean difference (MD) of 0.15 (95% confidence interval; 95% CI 0.05, 0.24); I2 = 99%. Longer telomere length was significantly associated with robust exercise (MD 0.08 (95% CI 0.04, 0.12)); I2 = 99%, as was moderate exercise (MD 0.07 (95% CI 0.03, 0.11)); I2 = 100%. Subgroup analysis revealed that longer telomere length was positively associated with exercise, regardless of sex, but was not statistically significant in elderly populations.
Compared with inactive individuals, telomere lengths were longer in active subjects, regardless of the intensity of exercise.
探讨不同运动水平对端粒长度的影响。
检索 CINAHL、SPORTDiscus（EBSCO）、OVID（Medline）和 EMBASE 数据库，以获取合格的研究。使用纽卡斯尔-渥太华量表评估方法学质量，并使用 I 平方检验评估研究之间的异质性。当研究之间存在高度异质性（I2>50%）时，使用随机效应模型（Cochrane 协作，丹麦哥本哈根的 Review Manager 版本 5）；否则，使用固定效应模型。
本荟萃分析纳入了 11 项涉及 19292 名参与者的合格研究。端粒较长与积极运动的个体相关，平均差异（MD）为 0.15（95%置信区间；95%CI 0.05,0.24）；I2=99%。端粒较长与剧烈运动（MD 0.08（95%CI 0.04,0.12））；I2=99%显著相关，中度运动（MD 0.07（95%CI 0.03,0.11））；I2=100%。亚组分析表明，无论性别如何，端粒长度与运动呈正相关，但在老年人群中无统计学意义。
与不活跃的个体相比，活跃的个体的端粒长度更长，无论运动强度如何。
