Oregon Center for Aging & Technology (ORCATECH), Oregon Health & Science University, Portland.
Internal Medicine and Gerontology, University Hospital of Toulouse, France.
J Gerontol A Biol Sci Med Sci. 2020 Apr 17;75(5):968-973. doi: 10.1093/gerona/glz128.
Although there are known clinical measures that may be associated with risk of future falls in older adults, we are still unable to predict when the fall will happen. Our objective was to determine whether unobtrusive in-home assessment of walking speed can detect a future fall.
In both ISAAC and ORCATECH Living Laboratory studies, a sensor-based monitoring system has been deployed in the homes of older adults. Longitudinal mixed-effects regression models were used to explore trajectories of sensor-based walking speed metrics in those destined to fall versus controls over time. Falls were captured during a 3-year period.
We observed no major differences between those destined to fall (n = 55) and controls (n = 70) at baseline in clinical functional tests. There was a longitudinal decline in median daily walking speed over the 3 months before a fall in those destined to fall when compared with controls, p < .01 (ie, mean walking speed declined 0.1 cm s-1 per week). We also found prefall differences in sensor-based walking speed metrics in individuals who experienced a fall: walking speed variability was lower the month and the week just before the fall compared with 3 months before the fall, both p < .01.
While basic clinical tests were not able to differentiate who will prospectively fall, we found that significant variations in walking speed metrics before a fall were measurable. These results provide evidence of a potential sensor-based risk biomarker of prospective falls in community living older adults.
尽管有一些已知的临床测量方法可能与老年人未来跌倒的风险相关,但我们仍然无法预测跌倒何时会发生。我们的目的是确定非侵入性的家庭行走速度评估是否可以检测到未来的跌倒。
在 ISAAC 和 ORCATECH 生活实验室研究中,已经在老年人的家中部署了基于传感器的监测系统。使用纵向混合效应回归模型来探索在未来跌倒者(n=55)和对照组(n=70)随时间推移的基于传感器的行走速度指标轨迹。在 3 年期间捕获跌倒事件。
在基线时,在预定跌倒者(n=55)和对照组(n=70)之间的临床功能测试中没有发现重大差异。与对照组相比,在预定跌倒者中,在跌倒前 3 个月内,每日行走速度的中位数呈纵向下降,p<0.01(即,平均行走速度每周下降 0.1cm/s)。我们还发现跌倒前个体基于传感器的行走速度指标存在差异:与跌倒前 3 个月相比,跌倒当月和前一周的行走速度变异性降低,均 p<0.01。
虽然基本的临床测试无法区分谁将前瞻性跌倒,但我们发现跌倒前行走速度指标的显著变化是可以测量的。这些结果为社区生活中的老年人未来跌倒的潜在基于传感器的风险生物标志物提供了证据。