Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia.
Institute for Social Research, University of Michigan, Ann Arbor.
J Gerontol A Biol Sci Med Sci. 2019 Aug 16;74(9):1468-1474. doi: 10.1093/gerona/gly250.
Falls are the leading cause of injury-related mortality among older adults in the United States, but incidence and risk factors for fall-related mortality remain poorly understood. This study compared fall-related mortality incidence rate estimates from a nationally representative cohort with those from a national vital record database and identified correlates of fall-related mortality.
Cause-of-death data from the National Death Index (NDI; 1999-2011) were linked with eight waves from the Health and Retirement Study (HRS), a representative cohort of U.S. older adults (N = 20,639). Weighted fall-related mortality incidence rates were calculated and compared with estimates from the Centers for Disease Control and Prevention (CDC) vital record data. Fall-related deaths were identified using International Classification of Diseases (Version 10) codes. Person-time at risk was calculated from HRS entry until death or censoring. Cox proportional hazards models were used to identify individual-level factors associated with fall-related deaths.
The overall incidence rate of fall-related mortality was greater in HRS-NDI data (51.6 deaths per 100,000; 95% confidence interval: 42.04, 63.37) compared with CDC data (42.00 deaths per 100,000; 95% confidence interval: 41.80, 42.19). Estimated differences between the two data sources were greater for men and adults aged 85 years and older. Greater age, male gender, and self-reported fall history were identified as independent risk factors for fall-related mortality.
Incidence rates based on aggregate vital records may substantially underestimate the occurrence of and risk for fall-related mortality differentially in men, minorities, and relatively younger adults. Cohort-based estimates of individual fall-related mortality risk are important supplements to vital record estimates.
在美国,老年人因跌倒导致的伤害相关死亡率是导致伤害相关死亡的主要原因,但对与跌倒相关的死亡率的发生率和危险因素仍了解甚少。本研究比较了来自全国代表性队列的与跌倒相关的死亡率发生率估计值与来自国家生命记录数据库的估计值,并确定了与跌倒相关的死亡率相关因素。
国家死亡指数(NDI;1999-2011 年)的死因数据与健康与退休研究(HRS)的 8 个波次相关联,HRS 是美国老年人的代表性队列(N=20639)。计算了加权的与跌倒相关的死亡率发生率,并与疾病控制与预防中心(CDC)生命记录数据的估计值进行了比较。使用国际疾病分类(第 10 版)代码确定与跌倒相关的死亡。风险人时是从 HRS 入组到死亡或截尾的时间。使用 Cox 比例风险模型确定与跌倒相关的死亡相关的个体水平因素。
HRS-NDI 数据中的与跌倒相关的死亡率的总体发生率(51.6 例/100000;95%置信区间:42.04,63.37)高于 CDC 数据(42.00 例/100000;95%置信区间:41.80,42.19)。两种数据源之间的估计差异在男性和 85 岁及以上的成年人中更大。更大的年龄、男性性别和自我报告的跌倒史被确定为与跌倒相关的死亡率的独立危险因素。
基于汇总生命记录的发生率可能会大大低估男性、少数民族和相对较年轻的成年人中与跌倒相关的死亡率的发生和风险。基于队列的个体与跌倒相关的死亡率风险估计是生命记录估计的重要补充。