1 Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, Hunan, P.R. China.
2 Department of Cardiothoracic Surgery, The First Affiliated Hospital of University of South China, Hengyang, P.R. China.
DNA Cell Biol. 2019 Jul;38(7):597-606. doi: 10.1089/dna.2018.4552. Epub 2019 May 16.
Mitochondria are highly dynamic organelles beyond powerhouses of a cell. These components also play important roles in cell homeostasis by regulating cell function and phenotypic modulation. Atherosclerosis is the leading cause of morbidity and mortality in developed and developing countries. Mitochondrial dysfunction has been increasingly associated with the initiation and progression of atherosclerosis by elevating the production of reactive oxygen species and mitochondrial oxidative stress damage, mitochondrial dynamics dysfunction, and energy supply. In this review, we describe the progression of the link between mitochondrial dysfunction and atherosclerosis and its potential regulation mechanisms.
线粒体是高度动态的细胞器，不仅仅是细胞的动力源。这些组件还通过调节细胞功能和表型调节在细胞稳态中发挥重要作用。动脉粥样硬化是发达国家和发展中国家发病率和死亡率的主要原因。线粒体功能障碍通过增加活性氧物种和线粒体氧化应激损伤、线粒体动态功能障碍和能量供应的产生，与动脉粥样硬化的发生和发展的关系日益密切。在这篇综述中，我们描述了线粒体功能障碍与动脉粥样硬化之间的联系及其潜在的调节机制的进展。
