English J S, Swerdlow A J, MacKie R M, O'Doherty C J, Hunter J A, Clark J, Hole D J
Br Med J (Clin Res Ed). 1987 Jan 17;294(6565):152-4. doi: 10.1136/bmj.294.6565.152.
In a study of risk factors for the development of melanocytic naevi in relation to the pathogenesis of malignant melanoma 197 white adults were examined by four dermatologists and naevus counts correlated with several other features. Highly significant associations were found between large numbers of banal acquired melanocytic naevi and the ability to tan easily without burning (skin types 3 and 4; relative risk 4.6), brown or hazel eyes (relative risk 3.5), green or grey eyes (relative risk 3.5) and brown or black hair (relative risk 3.7). No significant associations with numbers of naevi were shown for parity or use of oral contraceptives or other steroid hormones. This is the first study to find any relation between melanocytic naevi and phenotypic factors in a white population.
在一项关于黑素细胞痣发生发展的危险因素与恶性黑色素瘤发病机制关系的研究中，4名皮肤科医生对197名白人成年人进行了检查，并将痣的数量与其他几个特征进行了关联分析。发现大量普通获得性黑素细胞痣与以下特征之间存在高度显著的关联：容易晒黑而不晒伤的能力（皮肤类型3和4；相对风险4.6）、棕色或淡褐色眼睛（相对风险3.5）、绿色或灰色眼睛（相对风险3.5）以及棕色或黑色头发（相对风险3.7）。未发现痣的数量与生育状况、口服避孕药或其他甾体激素的使用之间存在显著关联。这是第一项在白人人群中发现黑素细胞痣与表型因素之间存在任何关系的研究。
