Wadsworth Center, New York State Department of Health, Empire State Plaza, P.O. Box 509, Albany, NY 12201-0509, USA.
Wadsworth Center, New York State Department of Health, Empire State Plaza, P.O. Box 509, Albany, NY 12201-0509, USA; Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, NY, USA; Biochemistry Department, Faculty of Science and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Sci Total Environ. 2019 Apr 1;659:790-795. doi: 10.1016/j.scitotenv.2018.12.454. Epub 2018 Dec 31.
Glyphosate is one of the most widely used herbicides in the United States, which has led to its ubiquitous occurrence in food and water and regular detection in human urine at concentrations of 1-10 μg/L. Data pertaining to health risks arising from the ingestion of glyphosate are limited and are the subject of much debate, which demands the need for more exposure information for this herbicide. Very little is known about glyphosate exposure in pets. In this study, we determined concentrations of glyphosate (Glyp) and its derivatives, methyl glyphosate (Me-Glyp) and aminomethylphosphonic acid (AMPA), in urine collected from 30 dogs and 30 cats from New York State, USA. Glyp was the most predominant compound found in pet urine followed by AMPA and Me-Glyp. The mean urinary concentration of ∑Glyp (sum of Glyp + Me-Glyp + AMPA) in cats (mean: 33.8 ± 46.7 ng/mL) was 2-fold higher than that in dogs (mean: 16.8 ± 24.4 ng/mL). Cumulative daily intakes (CDI) of Glyp in dogs and cats estimated from the urinary concentrations were, on average, 0.57 and 1.37 μg/kg bw/d, respectively. The exposure doses were two to four orders of magnitude below the current acceptable daily intake (ADI) suggested by several international health organizations for humans.
在美国，草甘膦是使用最广泛的除草剂之一，这导致它在食物和水中无处不在，并且在人类尿液中以 1-10μg/L 的浓度定期检测到。关于因摄入草甘膦而产生的健康风险的数据有限，并且存在很多争议，这就需要更多关于这种除草剂的暴露信息。关于宠物接触草甘膦的情况知之甚少。在这项研究中，我们确定了来自美国纽约州的 30 只狗和 30 只猫尿液中草甘膦（Glyp）及其衍生物甲基草甘膦（Me-Glyp）和氨甲基膦酸（AMPA）的浓度。Glyp 是宠物尿液中最主要的化合物，其次是 AMPA 和 Me-Glyp。猫尿液中∑Glyp（Glyp+Me-Glyp+AMPA 的总和）的平均尿浓度（mean：33.8±46.7ng/mL）比狗（mean：16.8±24.4ng/mL）高 2 倍。从尿液浓度估计的狗和猫的草甘膦累积日摄入量（CDI）分别为 0.57μg/kg bw/d 和 1.37μg/kg bw/d。暴露剂量比几个国际卫生组织为人类建议的当前可接受日摄入量（ADI）低两个到四个数量级。
