Feng Lei, Fan Gong-Lin, Zhang Jie, Wang Xiao, Zhu Jiang
Eye Center, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou.
Department of Ultrasound, Sir Run Run Shaw Hospital, College of Medicine Zhe Jiang University, Hangzhou.
Medicine (Baltimore). 2019 May;98(20):e15655. doi: 10.1097/MD.0000000000015655.
Multispectral imaging (MSI) shows increasing strengths in detection of retinal and choroidal disease. The aim of this study was to evaluate the capacity of javascript:void(0), detecting retinal and choroidal abnormalities of uveitis which have not been described previously.
The first case was a 49-year-old male patient who presented with visual disturbance and metamorphopsia in both eyes for 5 days, companying by a history of headache and hearing loss recently. The second case was related to a 45-year-old female patient who complained of blurred vision and a dark shadow before her right eye for 3 months. The third case corresponded to a 36-year-old male patient who presented with blurred vision and slight pain in his left eye for >1 week, and his blood tested positive for syphilis.
Three Chinese patients with representative kind of uveitis were described in the study, including Vogt-Koyanagi-Harada syndrome, posterior uveitis with choroidal neovascularization, and syphilis-infected uveitis. Each affected eye had corresponding retinal and choroidal abnormalities evaluated by multiple ophthalmologic examinations.
Case 1 was treated with oral prednisone at a dose of 1 mg/kg/d started at the early stage and then slowed tapering of the prednisone dose based on follow-up examinations. Case 2 received anti-VEGF treatment. Case 3 received the standard treatment for neurosyphilis.
Due to timely diagnosis and treatment, all patients had a better prognosis.
MSI provides a novel way to view retinal and choroidal abnormalities of uveitis, and may provide a supplemental method to morphological changes.
多光谱成像（MSI）在视网膜和脉络膜疾病检测中显示出越来越强的优势。本研究的目的是评估javascript:void(0)检测先前未描述的葡萄膜炎视网膜和脉络膜异常的能力。
第一例是一名49岁男性患者，双眼出现视力障碍和视物变形5天，近期伴有头痛和听力丧失史。第二例是一名45岁女性患者，右眼视物模糊和眼前黑影3个月。第三例是一名36岁男性患者，左眼视力模糊和轻微疼痛超过1周，血液梅毒检测呈阳性。
本研究描述了3例具有代表性葡萄膜炎的中国患者，包括Vogt-小柳原田综合征、伴有脉络膜新生血管的后葡萄膜炎和梅毒感染性葡萄膜炎。通过多项眼科检查评估每只患眼相应的视网膜和脉络膜异常情况。
病例1在早期开始口服泼尼松，剂量为1mg/kg/d，然后根据随访检查逐渐缓慢减少泼尼松剂量。病例2接受抗VEGF治疗。病例3接受神经梅毒的标准治疗。
由于诊断和治疗及时，所有患者预后较好。
MSI为观察葡萄膜炎的视网膜和脉络膜异常提供了一种新方法，可能为形态学改变提供一种补充方法。
