Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Department of Ophthalmology, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen, China.
Ocul Immunol Inflamm. 2021 Nov 17;29(7-8):1417-1423. doi: 10.1080/09273948.2020.1751212. Epub 2020 May 14.
: To analyze quantitative OCT-angiography (OCTA) measurements of Vogt-Koyanagi-Harada (VKH) disease at different disease stages.: OCTA scans of 110 VKH patients in acute uveitic, convalescent and chronic recurrent stage were reviewed; posterior uveitis recurrent cases were excluded. Superficial and deep capillary plexus (SCP and DCP) vascular densities (VD) and subfoveal choroidal thickness (SFCT) were compared.: DCP VD was significantly lower and SFCT higher in VKH than normal controls (NC) in all 3 stages (all < .001). Anterior uveitis recurrent patients had lower SCP and DCP VDs and thicker SFCT than convalescent patients ( = .001, < .001, and = .003, respectively). DCP VD was significantly correlated with visual acuity ( < .05). Patients with history of anterior recurrence had lower retinal VDs in the convalescent stage than those without ( < .001).: Retinal microcirculation is impaired in VKH. DCP VD might be a sensitive indicator of inflammatory status and appeared to be well associated with visual outcome.
分析不同疾病阶段 Vogt-Koyanagi-Harada（VKH）病的定量 OCT 血管造影（OCTA）测量结果。
回顾了 110 例急性葡萄膜炎、恢复期和慢性复发性 VKH 患者的 OCTA 扫描；排除了后葡萄膜炎复发性病例。比较了浅层和深层毛细血管丛（SCP 和 DCP）血管密度（VD）和中心凹下脉络膜厚度（SFCT）。
在所有 3 个阶段，DCP VD 均显著低于 VKH 正常对照组（NC）（均 <.001），SFCT 更高（均 <.001）。前葡萄膜炎复发性患者的 SCP 和 DCP VD 低于恢复期患者（=.001， <.001 和=.003）。DCP VD 与视力显著相关（<.05）。有前葡萄膜炎复发史的患者在恢复期的视网膜 VD 低于无复发史的患者（<.001）。
VKH 患者视网膜微循环受损。DCP VD 可能是炎症状态的敏感指标，与视力结果密切相关。
