Gunawan Prastiya Indra, Saharso Darto, Sari Dian Purnama
Division of Neurology, Department Of Child Health, Airlangga University, Soetomo Hospital, Surabaya, Indonesia.
Korean J Pediatr. 2019 Jul;62(7):281-285. doi: 10.3345/kjp.2018.07017. Epub 2019 May 8.
To evaluate the association between elevated S100B levels with brain tissue damage seen in abnormalities of head magnetic resonance imaging (MRI; diffusion tensor imaging [DTI] sequence) in patients with status epilepticus (SE).
An analytical observational study was conducted in children hospitalized at Dr Soetomo Hospital, Surabaya, from July to December 2016. The patients were divided into 2 groups: SE included all children with a history of SE; control included all children with febrile seizure. Blood samples of patients were drawn within 24 hours after admission. SE patients also underwent cranial MRI with additional DTI sequencing. The Mann-Whitney test and Spearman test were used for statistical analysis.
Fifty-three patients were enrolled the study. In the 24 children with SE who met the inclusion criteria, serum S100B and cranial MRI findings were assessed. Twenty-two children admitted with febrile seizures became the control group. Most patients were male (66.7%); the mean age was 35.8 months (standard deviation, 31.09). Mean S100B values of the SE group (3.430±0.141 μg/L) and the control group (2.998±0.572 μg/L) were significantly different (P<0.05). A significant difference was noted among each level of encephalopathy based on the cranial MRI results with serum S100B levels and the correlation was strongly positive with a coefficient value of 0.758 (P<0.001).
In SE patients, there is an increase of serum S100B levels within 24 hours after seizure, which has a strong positive correlation with brain damage seen in head MRI and DTI.
评估癫痫持续状态（SE）患者血清S100B水平升高与头部磁共振成像（MRI；弥散张量成像[DTI]序列）异常所显示的脑组织损伤之间的关联。
2016年7月至12月在泗水苏托莫医院住院的儿童中进行了一项分析性观察研究。患者分为两组：SE组包括所有有SE病史的儿童；对照组包括所有热性惊厥儿童。患者入院后24小时内采集血样。SE组患者还接受了头颅MRI及额外的DTI序列检查。采用Mann-Whitney检验和Spearman检验进行统计分析。
53例患者纳入研究。对符合纳入标准的24例SE患儿进行了血清S100B和头颅MRI检查结果评估。22例因热性惊厥入院的儿童作为对照组。大多数患者为男性（66.7%）；平均年龄为35.8个月（标准差，31.09）。SE组（3.430±0.141μg/L）和对照组（2.998±0.572μg/L）的平均S100B值有显著差异（P<0.05）。根据头颅MRI结果，各脑病水平与血清S100B水平之间存在显著差异，且相关性呈强正相关，系数值为0.758（P<0.001）。
在SE患者中，癫痫发作后24小时内血清S100B水平升高，与头颅MRI和DTI显示的脑损伤呈强正相关。
