小儿急性脑炎综合征中血清神经元特异性烯醇化酶升高。
Serum neuron specific enolase is increased in pediatric acute encephalitis syndrome.
作者信息
Pratamastuti Dian, Indra Gunawan Prastiya, Saharso Darto
机构信息
Post Graduate PhD Program, College of Medicine, Airlangga University, Surabaya, Indonesia.
Division of Pediatric Neurology, Department of Pediatrics, College of Medicine, Airlangga University, Soetomo Hospital , Surabaya, Indonesia.
出版信息
Korean J Pediatr. 2017 Sep;60(9):302-306. doi: 10.3345/kjp.2017.60.9.302. Epub 2017 Sep 21.
PURPOSE
This study aimed to investigate whether serum neuron-specific enolase (NSE) was expressed in acute encephalitis syndrome (AES) that causes neuronal damage in children.
METHODS
This prospective observational study was conducted in the pediatric neurology ward of Soetomo Hospital. Cases of AES with ages ranging from 1 month to 12 years were included. Cases that were categorized as simple and complex febrile seizures constituted the non-AES group. Blood was collected for the measurement of NSE within 24 hours of hemodynamic stabilization. The median NSE values of both groups were compared by using the Mann-Whitney test. All statistical analyses were performed with SPSS version 12 for Windows.
RESULTS
In the study period, 30 patients were enrolled. Glasgow Coma Scale mostly decreased in the AES group by about 40% in the level ≤8. All patients in the AES group suffered from status epilepticus and 46.67% of them had body temperature >40℃. Most of the cases in the AES group had longer duration of stay in the hospital. The median serum NSE level in the AES group was 157.86 ng/mL, and this value was significantly higher than that of the non-AES group (10.96 ng/mL; <0.05).
CONCLUSION
AES cases showed higher levels of serum NSE. These results indicate that serum NSE is a good indicator of neuronal brain injury.
目的
本研究旨在调查血清神经元特异性烯醇化酶（NSE）是否在导致儿童神经元损伤的急性脑炎综合征（AES）中表达。
方法
本前瞻性观察性研究在苏托莫医院儿科神经科病房进行。纳入年龄在1个月至12岁之间的AES病例。分类为简单和复杂热性惊厥的病例构成非AES组。在血流动力学稳定后24小时内采集血液用于检测NSE。使用曼-惠特尼检验比较两组的NSE中位数。所有统计分析均使用Windows版SPSS 12进行。
结果
在研究期间，共纳入30例患者。格拉斯哥昏迷量表评分在AES组中大多下降，在≤8分水平下降约40%。AES组所有患者均患有癫痫持续状态，其中46.67%的患者体温>40℃。AES组大多数病例住院时间更长。AES组血清NSE中位数水平为157.86 ng/mL，该值显著高于非AES组（10.96 ng/mL；P<0.05）。
结论
AES病例血清NSE水平较高。这些结果表明血清NSE是脑神经元损伤的良好指标。
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