疟疾对巴西亚马孙地区城市周边社区儿童认知功能的影响。
Malaria impact on cognitive function of children in a peri-urban community in the Brazilian Amazon.
机构信息
Fundação de Vigilância em Saúde do Amazonas, Manaus, Brazil.
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
出版信息
Malar J. 2019 May 16;18(1):173. doi: 10.1186/s12936-019-2802-2.
BACKGROUND
In Latin America, where Plasmodium vivax malaria is more prevalent, it is known that this species plays an important role in the sustainability of transmission, and can have an impact on morbidity in terms of anaemia, nutritional status, and cognitive development in children.
METHODS
The present study aimed to assess the impact of malaria infection on cognition of children in a peri-urban community in the Brazilian Amazon with moderate endemicity by applying Home Inventory and WPPSI-IV. A non-concurrent cohort study was designed and the cognitive, haematological, and nutritional profiles of the children were assessed. Children with documented malaria history were identified from official reported data.
RESULTS
A total of 219 children aged between 2 and 7 years were enrolled. Although 205 (95%) children had normal birth weight, 177 (81%) were malnourished, and 35 (16%) had anaemia. Among the 100 (46%) children who experienced at least one episode of malaria, 89 (89%) children demonstrated low level of cognitive development. The findings showed that Plasmodium vivax malaria was an independent risk factor for low cognitive development.
CONCLUSIONS
In addition to the known economic impact of malaria in the Amazon region, the study highlights the deleterious effects P. vivax malaria has on the socio-cultural development of the population.
背景
在拉丁美洲，间日疟更为流行，人们已经认识到该物种在传播的可持续性方面发挥着重要作用，并可能对贫血、营养状况和儿童认知发展等方面的发病率产生影响。
方法
本研究旨在通过家庭清单和 WPPSI-IV 评估巴西亚马逊地区中度流行的城市周边社区中疟疾感染对儿童认知的影响。设计了一项非同期队列研究，并评估了儿童的认知、血液学和营养状况。从官方报告的数据中确定有记录的疟疾病史的儿童。
结果
共纳入了 219 名 2 至 7 岁的儿童。尽管 205 名（95%）儿童出生体重正常，但 177 名（81%）儿童营养不良，35 名（16%）儿童贫血。在经历至少一次疟疾发作的 100 名（46%）儿童中，89 名（89%）儿童认知发育水平较低。研究结果表明，间日疟是认知发育不良的独立危险因素。
结论
除了疟疾在亚马逊地区已知的经济影响外，该研究还强调了间日疟对该地区人口社会文化发展的有害影响。
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