Nandish Prerana, B M Shrinivasa, N Sujith Nath, Shankar G, Tripathi Praveen Kumar, Kashyap Himani, Jain Animesh, Anvikar Anup, Chalageri Vani H
Indian Council of Medical Research, National Institute of Malaria Research, Bengaluru, Karnataka, India.
Indian Council of Medical Research, National Institute of Malaria Research, Ranchi, Jharkhand, India.
Front Hum Neurosci. 2024 Jul 18;18:1432441. doi: 10.3389/fnhum.2024.1432441. eCollection 2024.
Malaria morbidity has various presentations and the focus now shifts to uncommon signs and symptoms of malaria infection such as cognitive impairment to address the morbidity when the mortality declines. About 50% of children admitted to hospitals due to malaria experience neurological complications due to factors like low blood sugar, inflammation, elevated pressure, decreased oxygen levels, and excitotoxicity. Malaria during pregnancy negatively also impacts children's cognitive, behavioral, and executive function leading to neurodevelopmental delay due to increased susceptibility which can significantly affect maternal and child health, leading to higher rates of underestimated factors like anxiety, depression, and PTSD. Despite having the world's second-largest tribal population, India's indigenous and tribal communities and their mental health are less explored and less understood. Western psychological tools and neurocognitive assessment tools are not universally applicable, thus necessitating the development of tailored tools to investigate psychological or neurocognitive impairment. This paper has illuminated the hidden mental health consequences of malaria infection, emphasizing the prevalence, nature, and implications of psychological distress among affected individuals. The findings underscore the importance of recognizing and addressing these psychological consequences in the holistic management and prevention of malaria and its mental health consequences.
疟疾的发病表现多种多样，现在重点转向疟疾感染的罕见体征和症状，如认知障碍，以便在死亡率下降时应对发病情况。因疟疾住院的儿童中，约50%会因低血糖、炎症、压力升高、氧含量降低和兴奋毒性等因素出现神经并发症。孕期疟疾也会对儿童的认知、行为和执行功能产生负面影响，导致神经发育迟缓，因为易感性增加会显著影响母婴健康，导致焦虑、抑郁和创伤后应激障碍等未被充分认识的因素发生率更高。尽管印度拥有世界第二大部落人口，但对其本土和部落社区及其心理健康的探索和了解较少。西方心理工具和神经认知评估工具并不普遍适用，因此需要开发量身定制的工具来调查心理或神经认知障碍。本文阐明了疟疾感染隐藏的心理健康后果，强调了受影响个体心理困扰的患病率、性质和影响。研究结果强调了在疟疾及其心理健康后果的整体管理和预防中认识并应对这些心理后果的重要性。
