Khemiri S, Ben Thabet J, Ben Kridis W, Maalej M, Khanfir A, Frikha M
Department of oncology, Habib-Bourguiba hospital, Sfax, Tunisia.
Department of psychiatry, Hédi-Chaker hospital, Sfax, Tunisia.
Cancer Radiother. 2019 Jun;23(3):188-193. doi: 10.1016/j.canrad.2018.09.002. Epub 2019 May 13.
Pain often induces in cancer patient emotional disorders such as anxiety, depression and alteration of quality of life. The purpose of our work was to assess the impact of the intensity of pain and those characteristics on anxiety, depression state and quality of life of cancer patients.
This is an analytical cross-sectional study including 106 cancer patients with pain. We evaluated four parameters: pain intensity by visual analogue scale, the presence of anxiety and of depression using the Hospital Anxiety and Depressive Scale, and the alteration of quality of life by 36-item Short-Form Health Survey.
Patients' average age was 55 years old. The sex ratio was 0.79. Pain intensity was low in 16%, moderate in 49.1% and intense in 34.9% of patients. The prevalence of anxiety and depression was 49.1% and 54% of patients, respectively. The independent factors correlated to the occurrence of anxiety were: pain intensity, bone localization, continuous progression, chronicity of pain, advanced stage, hospitalization at day hospital, the partial or no response to analgesic treatment. The independent factors correlated to the onset of depression were: intensity of pain, advanced stage of the disease, bone localization, step 2 or 3 of analgesic, and partial or no response to analgesic treatment.
The prevalence of anxiety and depression in our patients was slightly higher than those reported in the literature. The main factors correlated with the onset of depression and anxiety were: severe pain, bone location, and advanced stage of the disease.
疼痛常诱发癌症患者出现焦虑、抑郁等情绪障碍以及生活质量改变。我们研究的目的是评估疼痛强度及相关特征对癌症患者焦虑、抑郁状态和生活质量的影响。
这是一项分析性横断面研究，纳入106例伴有疼痛的癌症患者。我们评估了四个参数：采用视觉模拟量表评估疼痛强度，使用医院焦虑抑郁量表评估焦虑和抑郁的存在情况，以及通过36项简明健康调查问卷评估生活质量的改变。
患者的平均年龄为55岁。性别比为0.79。16%的患者疼痛强度低，49.1%的患者疼痛强度中等，34.9%的患者疼痛强度高。焦虑和抑郁的患病率分别为49.1%和54%。与焦虑发生相关的独立因素有：疼痛强度、骨转移部位、持续进展、疼痛慢性化、晚期、日间医院住院、对镇痛治疗部分或无反应。与抑郁发生相关的独立因素有：疼痛强度、疾病晚期、骨转移部位、镇痛治疗的第2或3阶段、对镇痛治疗部分或无反应。
我们患者中焦虑和抑郁的患病率略高于文献报道。与抑郁和焦虑发生相关的主要因素有：重度疼痛、骨转移部位和疾病晚期。
