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The carrier state for sickle cell disease is not completely harmless.

作者信息

Xu Julia Zhe, Thein Swee Lay

机构信息

Sickle Cell Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MA, USA.

Sickle Cell Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MA, USA

出版信息

Haematologica. 2019 Jun;104(6):1106-1111. doi: 10.3324/haematol.2018.206060. Epub 2019 May 16.

DOI:10.3324/haematol.2018.206060
PMID:31097635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6545856/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e80/6545856/06259e35a6ae/1041106.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e80/6545856/cb4dad1b690f/1041106.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e80/6545856/06259e35a6ae/1041106.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e80/6545856/cb4dad1b690f/1041106.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e80/6545856/06259e35a6ae/1041106.fig2.jpg

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2
Clinical Outcomes Associated With Sickle Cell Trait: A Systematic Review.镰状细胞特征与临床结局的关联：系统评价。
Ann Intern Med. 2018 Nov 6;169(9):619-627. doi: 10.7326/M18-1161. Epub 2018 Oct 30.
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Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease.常见的α-珠蛋白变异可改变镰状细胞特征和疾病的血液学和其他临床表型。
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Int Orthop. 2025 May 7. doi: 10.1007/s00264-025-06555-8.
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Preimplantation Genetic Testing (PGT) to Reduce the Risk for GBA-Related Parkinson's Disease: Expanding the Applications for Embryo Selection.植入前基因检测（PGT）以降低与GBA相关帕金森病的风险：扩大胚胎选择的应用范围
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