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二酰基甘油诱导的人黑素瘤和原代黑素细胞黑素生成的调节：应激伴侣mortalin的作用

Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin.

作者信息

Wadhwa Renu, Li Ling, Singh Rumani, Wang Jia, Gao Ran, Nigam Nupur, Forestier Sandra, Ando Nobuhiro, Kaul Sunil C

机构信息

DAILAB, DBT-AIST International Center for Translational and Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305-8565, Japan.

KK Chanel Research and Technology Development Laboratory, 1-1-5, Yamate, Funabashi-Chiba 273-0045, Japan.

出版信息

Evid Based Complement Alternat Med. 2019 Apr 14;2019:9848969. doi: 10.1155/2019/9848969. eCollection 2019.

DOI:10.1155/2019/9848969
PMID:31097976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6487102/
Abstract

Skin color/pigmentation is regulated through melanogenesis process in specialized melanin-producing cells, melanocytes, involving multiple signaling pathways. It is highly influenced by intrinsic and extrinsic factors such as oxidative, ultraviolet radiations and other environmental stress conditions. Besides determining the color, it governs response and tolerance of skin to a variety of environmental stresses and pathological conditions including photodamage, hyperpigmentation, and skin cancer. Depigmenting reagents have been deemed useful not only for cosmetics but also for pigmentation-related pathologies. In the present study, we attempted modulation of 1-oleoyl-2-acetyl-glycerol- (OAG-) induced melanogenesis in human melanoma and primary melanocytes. In both cell types, OAG-induced melanogenesis was associated with increase in enhanced expression of melanin, tyrosinase, as well as stress chaperones (mortalin and HSP60) and Reactive Oxygen Species (ROS). Treatment with TXC (trans-4-(Aminomethyl) cyclohexanecarboxylic acid hexadecyl ester hydrochloride) and 5/40 natural compounds resulted in their reduction. The data proposed an important role of mortalin and oxidative stress in skin pigmentation and the use of TXC and natural extracts for modulation of pigmentation pathways in normal and pathological conditions.

摘要

皮肤颜色/色素沉着是通过在专门的产生黑色素的细胞即黑素细胞中的黑色素生成过程来调节的，这一过程涉及多个信号通路。它受到内在和外在因素的高度影响，如氧化、紫外线辐射和其他环境应激条件。除了决定肤色外，它还控制皮肤对各种环境应激和病理状况的反应及耐受性，这些状况包括光损伤、色素沉着过度和皮肤癌。色素脱失试剂不仅被认为对化妆品有用，而且对与色素沉着相关的病理状况也有用。在本研究中，我们尝试调节1-油酰基-2-乙酰甘油（OAG）诱导的人黑色素瘤细胞和原代黑素细胞中的黑色素生成。在这两种细胞类型中，OAG诱导的黑色素生成与黑色素、酪氨酸酶以及应激伴侣蛋白（mortalin和HSP60）和活性氧（ROS）表达增强的增加有关。用TXC（反式-4-（氨甲基）环己烷羧酸十六烷基酯盐酸盐）和5/40种天然化合物处理导致它们减少。数据表明mortalin和氧化应激在皮肤色素沉着中起重要作用，以及TXC和天然提取物在正常和病理条件下对色素沉着途径的调节作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2e0/6487102/323ef3a96add/ECAM2019-9848969.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2e0/6487102/79e47b5a0c5a/ECAM2019-9848969.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2e0/6487102/f2eb8137f307/ECAM2019-9848969.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2e0/6487102/8d043b15527e/ECAM2019-9848969.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2e0/6487102/9981d470c21d/ECAM2019-9848969.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2e0/6487102/323ef3a96add/ECAM2019-9848969.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2e0/6487102/79e47b5a0c5a/ECAM2019-9848969.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2e0/6487102/f2eb8137f307/ECAM2019-9848969.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2e0/6487102/8d043b15527e/ECAM2019-9848969.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2e0/6487102/9981d470c21d/ECAM2019-9848969.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2e0/6487102/323ef3a96add/ECAM2019-9848969.005.jpg

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本文引用的文献

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自噬功能障碍：一种可能通过打破黑素细胞氧化还原平衡参与白癜风发病机制的机制。
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Stress chaperone mortalin regulates human melanogenesis.应激伴侣蛋白mortalin调节人类黑色素生成。
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