L'OREAL Research and Innovation, Aulnay-sous-Bois, France.
Department of Dermatology, University of Cincinnati, Cincinnati, Ohio, USA.
J Invest Dermatol. 2014 Jun;134(6):1512-1518. doi: 10.1038/jid.2014.65. Epub 2014 Feb 27.
Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state generated during melanin synthesis, and to the intrinsic antioxidant defenses that are compromised in pathologic conditions. Melanoma is thought to be oxidative stress driven, and melanocyte death in vitiligo is thought to be instigated by a highly pro-oxidant state in the epidermis. We review the current knowledge about melanin and the redox state of melanocytes, how paracrine factors help counteract oxidative stress, the role of oxidative stress in melanoma initiation and progression and in melanocyte death in vitiligo, and how this knowledge can be harnessed for melanoma and vitiligo treatment.
表皮黑素细胞特别容易受到氧化应激的影响，因为在黑色素合成过程中会产生促氧化剂状态，并且在病理条件下内在的抗氧化防御会受到损害。黑色素瘤被认为是由氧化应激驱动的，而白癜风中黑素细胞的死亡被认为是由表皮中高度促氧化剂状态引发的。我们回顾了有关黑色素和黑素细胞氧化还原状态的现有知识，旁分泌因子如何帮助对抗氧化应激，氧化应激在黑色素瘤的发生和进展以及白癜风中黑素细胞死亡中的作用，以及如何利用这些知识来治疗黑色素瘤和白癜风。
