Li Zhen-Li, Han Jun, Liu Kai, Xing Hao, Wu Han, Lau Wan Yee, Pawlik Timothy M, Li Chao, Wang Ming-Da, Yu Jiong-Jie, Wu Meng-Chao, Shen Feng, Yang Tian
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Hepatobiliary Surg Nutr. 2019 Apr;8(2):88-100. doi: 10.21037/hbsn.2018.11.20.
Family history is a risk factor for the development of hepatocellular carcinoma (HCC). The aim of the current study was to investigate the association between family history of HCC and long-term oncologic prognosis among patients undergoing curative liver resection for hepatitis B virus (HBV)-related HCC.
Patients who underwent curative liver resection of HBV-related HCC between 2003 and 2013 were consecutively enrolled. Family history was defined as a self-reported history of HCC in a first-degree relative. Propensity score matching (PSM) and multivariable Cox-regression analyses were performed to compare overall survival (OS) and recurrence-free survival (RFS) among patients with and without a family history.
Among 1,112 patients, 183 (16.5%) patients had a family history of HCC. Using PSM, 179 pairs of patients with and without a family history were created that had no differences in the baseline characteristics and operative variables. On matched analysis, family history was associated with decreased OS and RFS after curative-intent resection of HBV-related HCC in the propensity matching cohort (P=0.042 and 0.006, respectively). On multivariable Cox-regression analyses, a family history of HCC was associated with decreased OS (HR: 1.574; 95% CI: 1.171-2.116; P=0.003) and RFS (HR: 1.534; 95% CI: 1.176-2.002; P=0.002) after adjusting for other prognostic risk factors.
Family history was associated with decreased OS and RFS rates among patients undergoing curative liver resection of HBV-related HCC.
家族史是肝细胞癌（HCC）发生的一个危险因素。本研究的目的是调查HBV相关HCC行根治性肝切除患者的HCC家族史与长期肿瘤学预后之间的关联。
连续纳入2003年至2013年间接受HBV相关HCC根治性肝切除的患者。家族史定义为一级亲属中有自我报告的HCC病史。采用倾向评分匹配（PSM）和多变量Cox回归分析比较有和没有家族史患者的总生存期（OS）和无复发生存期（RFS）。
在1112例患者中，183例（16.5%）有HCC家族史。通过PSM，创建了179对有和没有家族史的患者，他们在基线特征和手术变量方面没有差异。在匹配分析中，在倾向匹配队列中，家族史与HBV相关HCC根治性切除术后OS和RFS降低相关（P分别为0.042和0.006）。在多变量Cox回归分析中，校正其他预后危险因素后，HCC家族史与OS降低（HR：1.574；95%CI：1.171 - 2.116；P = 0.003）和RFS降低（HR：1.534；95%CI：1.176 - 2.002；P = 0.002）相关。
家族史与HBV相关HCC行根治性肝切除患者的OS和RFS率降低相关。
