Ro 23 - 6240对敏感和耐药细胞内分枝杆菌的作用。

Effect of Ro 23-6240 on sensitive and resistant intracellular mycobacteria.

作者信息

Easmon C, Verity L

出版信息

Eur J Clin Microbiol. 1987 Apr;6(2):165-6. doi: 10.1007/BF02018200.

DOI:10.1007/BF02018200

Abstract

The activity of Ro 23-6240 and rifampicin against intracellular Mycobacterium fortuitum and Mycobacterium chelonei was assessed in vitro over a 48-hour period. Both agents, at an extracellular concentration of 2.0 mg/l (Ro 23-6240) and 1.0 mg/l (rifampicin), produced a significant intracellular killing of the sensitive Mycobacterium fortuitum at both 20 and 48 hours. However, neither agent was effective against the resistant Mycobacterium chelonei. It was concluded that Ro 23-6240 has a direct antimicrobial effect against sensitive intracellular mycobacteria.

摘要

在48小时内对Ro 23 - 6240和利福平针对细胞内偶然分枝杆菌和龟分枝杆菌的活性进行了体外评估。两种药物，细胞外浓度为2.0毫克/升（Ro 23 - 6240）和1.0毫克/升（利福平），在20小时和48小时时对敏感的偶然分枝杆菌均产生了显著的细胞内杀菌作用。然而，两种药物对耐药的龟分枝杆菌均无效。得出的结论是，Ro 23 - 6240对敏感的细胞内分枝杆菌具有直接抗菌作用。