依诺沙星对分枝杆菌体外活性的初步研究。

Preliminary study of the in vitro activity of irloxacin against mycobacteria.

作者信息

Casal M, Gutierrez J, Ruiz P, Moreno G

机构信息

Department of Medical Microbiology, Córdoba University, Spain.

出版信息

Chemotherapy. 1995 May-Jun;41(3):204-7. doi: 10.1159/000239345.

DOI:10.1159/000239345

PMID:7656667

Abstract

Today Mycobacterium avium and Mycobacterium tuberculosis multidrug resistance are responsible for frequent and severe infections in humans and especially in AIDS patients. Irloxacin is a new quinolone derivative, and shows greater activity with an acid pH. It has a good in vitro antimicrobial spectrum against both gram-positive and gram-negative bacteria. We have compared the in vitro activity of irloxacin against mycobacteria (20 M. tuberculosis, 17 M. avium, 5 Mycobacterium bovis, 5 Mycobacterium chelonae, 5 Mycobacterium fortuitum and 1 Mycobacterium gadium) using the Bactec at pH 6.8 and 5.0, with other quinolones (ofloxacin, ciprofloxacin, pefloxacin and 27753 RP). All quinolones tested showed good activity against mycobacteria at pH 6.8 and 5.0. Irloxacin at pH 5.0 had a greater activity against M. avium.

摘要

如今，鸟分枝杆菌和结核分枝杆菌的多重耐药性导致人类尤其是艾滋病患者频繁发生严重感染。伊洛沙星是一种新型喹诺酮衍生物，在酸性pH条件下显示出更强的活性。它对革兰氏阳性菌和革兰氏阴性菌均具有良好的体外抗菌谱。我们使用Bactec法，在pH 6.8和5.0条件下，比较了伊洛沙星与其他喹诺酮类药物（氧氟沙星、环丙沙星、培氟沙星和27753 RP）对分枝杆菌（20株结核分枝杆菌、17株鸟分枝杆菌、5株牛分枝杆菌、5株龟分枝杆菌、5株偶发分枝杆菌和1株加地分枝杆菌）的体外活性。所有测试的喹诺酮类药物在pH 6.8和5.0条件下对分枝杆菌均显示出良好的活性。在pH 5.0条件下，伊洛沙星对鸟分枝杆菌的活性更强。