用于癌症治疗的环保型金纳米颗粒的设计

Design of Eco-Friendly Gold Nanoparticles for Cancer Treatment.

作者信息

Pooja Deep, Sistla Ramakrishna

机构信息

Pharmacology and Toxicology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.

出版信息

Methods Mol Biol. 2019;1974:215-221. doi: 10.1007/978-1-4939-9220-1_16.

DOI:10.1007/978-1-4939-9220-1_16

PMID:31099006

Abstract

Gold nanoparticles (GNPs) have emerged as a potential scaffold for a wide range of biomedical applications such as biosensing, drug delivery, and imaging. However, the toxicity of nanoparticles remains a challenge for using them in biological system. The morphology and surface chemistry of GNP can be manipulated by their method of preparation. GNP can be synthesized and functionalized by various methods. This chapter illustrates the synthesis of highly biocompatible GNP using a natural gum, i.e., xanthan gum (XG). Moreover, due to the presence of mannose moiety in XG, these XG-stabilized GNP may also act as self-targeted drug carriers for the delivery of chemotherapeutic agents/siRNA/shRNA to mannose receptor overexpressing cancer cells.

摘要

金纳米颗粒（GNPs）已成为一种潜在的支架，可用于广泛的生物医学应用，如生物传感、药物递送和成像。然而，纳米颗粒的毒性仍然是其在生物系统中应用的一个挑战。GNP的形态和表面化学性质可通过其制备方法进行调控。GNP可以通过多种方法合成并功能化。本章阐述了使用天然胶即黄原胶（XG）合成具有高度生物相容性的GNP。此外，由于XG中存在甘露糖部分，这些XG稳定的GNP还可作为自靶向药物载体，用于将化疗药物/小干扰RNA/短发夹RNA递送至过表达甘露糖受体的癌细胞。