城市性与首发精神病风险：巴西的一项发病研究。

Urbanicity and risk of first-episode psychosis: incidence study in Brazil.

机构信息

Associate Professor, Department of Neurosciences and Behaviour, Ribeirão Preto Medical School, University of São Paulo; and Vice Director, Population Mental Health Research Centre, University of São Paulo, Brazil.

Postdoctoral Fellow, Department of Neurosciences and Behaviour, Ribeirão Preto Medical School, University of São Paulo; and Research Fellow, Population Mental Health Research Centre, University of São Paulo, Brazil.

出版信息

Br J Psychiatry. 2019 Dec;215(6):726-729. doi: 10.1192/bjp.2019.110.

DOI:10.1192/bjp.2019.110

PMID:31099323

Abstract

We estimated the incidence of first-episode psychosis over a 3-year period in a Brazilian catchment area comprising the region's main city, Ribeirão Preto (1 425 306 persons-years at risk), and 25 other municipalities with a total of 1 646 556 persons-years at risk. The incidence rates were estimated and adjusted by gender and age, using the direct standardisation method to the world population as reference. The incidence of psychosis was higher in the younger groups, men, and among Black and minority ethnic Brazilians. Psychosis incidence was lower in Ribeirão Preto (16.69/100 000 person-years at risk; 95% CI 15.68-17.70) compared with the average incidence in the remaining municipalities (21.25/100 000 person-years at risk; 95% CI 20.20-22.31), which have lower population density, suggesting a distinct role for urbanicity in the incidence of first-episode psychosis in low- and middle-income countries.

摘要

我们在巴西的一个集水区（包括该地区的主要城市里贝拉奥普雷托[1425306 人年风险]和其他 25 个共有 1646556 人年风险的城市）内，对 3 年内首次出现精神病发作的情况进行了估计。发病率是通过性别和年龄进行估计和调整的，采用了世界人口作为参照的直接标准化方法。精神病的发病率在年轻人群、男性以及黑人及少数民族巴西人中更高。与剩余城市的平均发病率（21.25/100000 人年风险；95%CI 20.20-22.31）相比，里贝拉奥普雷托的精神病发病率较低（16.69/100000 人年风险；95%CI 15.68-17.70），这表明人口密度较低的城市在低中等收入国家首次出现精神病发作的发病率中起着明显的作用。