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电刺激大鼠脑尾状核和伏隔核对5-羟色胺能神经元的影响。

The effect of electric stimulation of caudate nucleus and nucleus accumbens septi on serotonergic neurons in the rat brain.

作者信息

Hano J, Przewłocki R, Smiałowska M, Chłapowska M, Rokosz-Pelc A

出版信息

Pol J Pharmacol Pharm. 1978 Jul-Aug;30(4):475-81.

PMID:310997
Abstract

Nucleus caudatus--putamen (CP) or nucleus accumbens septi (A) were stimulated electrically for 30 min in free moving rats. Immediately or 30 min after the stimulation we studied the level of 5-HTP and DOPA accumulated in the mesencephalon+pons+medulla oblongata, after inhibition of activity of aromatic amino acids decarboxylase by NSD 1015, and intensity of histofluorescence of serotonin in the midbrain raphe nuclei. The electrical stimulation of either structure did not significantly change the content of 5-HTP and DOPA, but stimulation of nucleus accumbens depressed the level of serotonin in the neurocytes of dorsal and ventral raphe nuclei.

摘要

在自由活动的大鼠中,对尾状核 - 壳核(CP)或伏隔核(A)进行30分钟的电刺激。在刺激后立即或30分钟后,我们研究了在通过NSD 1015抑制芳香族氨基酸脱羧酶活性后,中脑+脑桥+延髓中积累的5 - 羟色氨酸(5 - HTP)和多巴(DOPA)水平,以及中脑缝际核中血清素的组织荧光强度。对任一结构的电刺激均未显著改变5 - HTP和DOPA的含量,但刺激伏隔核会降低背侧和腹侧缝际核神经细胞中血清素的水平。

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