Brno Epilepsy Center, Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.
Clin Neurophysiol. 2019 Jul;130(7):1151-1159. doi: 10.1016/j.clinph.2019.03.026. Epub 2019 Apr 10.
The main aim of this study was to investigate the potential differences in terms of interictal high frequency oscillations (HFOs) between both hippocampi in unilateral (U-MTLE) and bilateral mesial temporal lobe epilepsy (B-MTLE).
Sixteen patients with MTLE underwent bilateral hippocampal depth electrode implantation as part of epilepsy surgery evaluation. Interictal HFOs were detected automatically. The analyses entail comparisons of the rates and spatial distributions of ripples and fast ripples (FR) in hippocampi and amygdalae, with respect to the eventual finding of hippocampal sclerosis (HS).
In U-MTLE, higher ripple and FR rates were found in the hippocampi ipsilateral to the seizure onset than in the contralateral hippocampi. Non-epileptic hippocampi in U-MTLE were distinguished by significantly lower ripple rate than in the remaining analyzed hippocampi. There were not differences between the hippocampi in B-MTLE. In the hippocampi with proven HS, higher FR rates were observed in the ventral than in the dorsal parts.
Non-epileptic hippocampi in U-MTLE demonstrated significantly lower ripple rates than those epileptic in U-MTLE and B-MTLE.
Low interictal HFO occurrence might be considered as a marker of the non-epileptic hippocampi in MTLE.
本研究的主要目的是探讨单侧颞叶癫痫（U-MTLE）和双侧颞叶内侧癫痫（B-MTLE）患者双侧海马间棘波（HFO）的潜在差异。
16 例 MTLE 患者接受双侧海马深部电极植入术作为癫痫手术评估的一部分。自动检测癫痫间期 HFO。分析包括比较海马和杏仁核中海马棘波和快棘波（FR）的频率和空间分布，以及海马硬化（HS）的最终发现。
在 U-MTLE 中，与对侧海马相比，起始发作同侧海马的棘波和 FR 率更高。U-MTLE 中的非癫痫性海马与其余分析的海马相比，棘波率显著降低。B-MTLE 中没有差异。在证实有 HS 的海马中，腹侧的 FR 率高于背侧。
U-MTLE 中的非癫痫性海马与 U-MTLE 和 B-MTLE 中的癫痫性海马相比，棘波率明显降低。
低癫痫间期 HFO 发生可能被认为是 MTLE 中非癫痫性海马的标志物。
