Qi Yuqing, Kong Jie, He Jinyan
Department of Dermatology and Venereology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, 300052, People's Republic of China.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, No. 22 Qixiangtai Road, Tianjin, 300070, People's Republic of China.
BMC Med Genet. 2019 May 17;20(1):83. doi: 10.1186/s12881-019-0817-8.
We retrieved different reports containing different genetic effects of - 1082 A/G, - 819 T/C, and - 592 A/C polymorphisms within the IL-10 (interleukin-10) gene on the susceptibility to clinical atopic dermatitis.
Herein, we conducted a meta-analysis to comprehensively assess such a genetic relationship after collecting the available published evidence. STATA 12.0 software was used for the statistical analysis under the allelic, homozygotic, heterozygotic, dominant, recessive and carrier genetic models.
By retrieving and screening database literature, a total of 16 eligible case-control studies were finally selected. For the IL-10 -1082 A/G polymorphism, we did not detect a significant difference between atopic dermatitis cases and population-based controls in the overall meta-analysis under the genetic models of allele G vs. A (P = 0.540), GG vs. AA (P = 0.853), AG vs AA (P = 0.265), AG + GG vs AA (P = 0.221), GG vs AA+AG (P = 0.540) and carrier G vs. A (P = 0.643). Moreover, a statistically non-significant association was observed in the most subgroup meta-analyses by the factors of ethnicity, country and Hardy-Weinberg equilibrium. Likewise, the negative results were detected for the synthetic analysis of IL-10 -819 T/C and - 592 C/A polymorphisms.
The current evidence does not support a strong genetic relationship between IL-10 -1082 A/G, - 819 T/C and - 592 A/C polymorphisms and the susceptibility to atopic dermatitis.
我们检索了不同的报告，这些报告包含白细胞介素-10（IL-10）基因中-1082 A/G、-819 T/C和-592 A/C多态性对临床特应性皮炎易感性的不同遗传效应。
在此，我们在收集现有已发表证据后进行了一项荟萃分析，以全面评估这种遗传关系。使用STATA 12.0软件在等位基因、纯合子、杂合子、显性、隐性和携带者遗传模型下进行统计分析。
通过检索和筛选数据库文献，最终共选择了16项符合条件的病例对照研究。对于IL-10 -1082 A/G多态性，在等位基因G与A（P = 0.540）、GG与AA（P = 0.853）、AG与AA（P = 0.265）、AG + GG与AA（P = 0.221）、GG与AA + AG（P = 0.540）以及携带者G与A（P = 0.643）的遗传模型下，我们在总体荟萃分析中未检测到特应性皮炎病例与基于人群的对照之间存在显著差异。此外，在按种族、国家和哈迪-温伯格平衡因素进行的大多数亚组荟萃分析中，观察到的关联在统计学上无显著意义。同样，对IL-10 -819 T/C和-592 C/A多态性的综合分析也得出了阴性结果。
目前的证据不支持IL-10 -1082 A/G、-819 T/C和-592 A/C多态性与特应性皮炎易感性之间存在强遗传关系。
