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Age and early maternal smoking contribute to epithelial cell IL-13 responsiveness in a pediatric asthma population.年龄和母亲孕期早期吸烟会导致儿童哮喘人群中上皮细胞对白细胞介素-13产生反应。
Allergy. 2019 Dec;74(12):2485-2487. doi: 10.1111/all.13876. Epub 2019 Jul 2.
2
Grandmaternal smoking increases asthma risk in grandchildren: A nationwide Swedish cohort.祖母吸烟会增加孙辈患哮喘的风险：一项全国性瑞典队列研究。
Clin Exp Allergy. 2018 Feb;48(2):167-174. doi: 10.1111/cea.13031. Epub 2017 Oct 10.
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Transgenerational transmission of asthma risk after exposure to environmental particles during pregnancy.孕期暴露于环境颗粒物后哮喘风险的跨代传递。
Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L395-L405. doi: 10.1152/ajplung.00035.2017. Epub 2017 May 11.
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Exposure to magnetic fields during pregnancy and asthma in offspring.孕期暴露于磁场与子代哮喘
Arch Pediatr Adolesc Med. 2012 Jan;166(1):97. doi: 10.1001/archpedi.166.1.97-a.
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Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B.母体柴油颗粒暴露通过 NK 细胞衍生的颗粒酶 B 促进后代哮喘。
J Clin Invest. 2020 Aug 3;130(8):4133-4151. doi: 10.1172/JCI130324.
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Are girls more susceptible to the effects of prenatal exposure to tobacco smoke on asthma?女孩是否更容易受到产前接触烟草烟雾对哮喘影响的影响？
Epidemiology. 2007 Sep;18(5):573-6. doi: 10.1097/EDE.0b013e31812001d2.
7
Interleukin-13 in asthma pathogenesis.白细胞介素-13在哮喘发病机制中的作用
Curr Allergy Asthma Rep. 2004 Mar;4(2):123-31. doi: 10.1007/s11882-004-0057-6.
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Perinatal smoking exposure and risk of asthma in the first three years of life: A prospective prebirth cohort study.围产期吸烟暴露与生命前三年哮喘风险：一项前瞻性产前队列研究。
Allergol Immunopathol (Madr). 2020 Nov-Dec;48(6):530-536. doi: 10.1016/j.aller.2020.03.008. Epub 2020 May 18.
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Impact of parental asthma, prenatal maternal asthma control, and vitamin D status on risk of asthma and recurrent wheeze in 3-year-old children.父母哮喘、孕期母亲哮喘控制情况和维生素 D 状况对 3 岁儿童哮喘和反复喘息风险的影响。
Clin Exp Allergy. 2019 Apr;49(4):419-429. doi: 10.1111/cea.13320. Epub 2019 Jan 3.
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Observations on power-line magnetic fields associated with asthma in children.
Arch Pediatr Adolesc Med. 2012 Jan;166(1):97-8; author reply 98-9. doi: 10.1001/archpedi.166.1.97-b.

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1
Increased nasal epithelial cell responsiveness to IL-17A in paediatric asthmatics with low blood neutrophil count, low traffic-related air pollution exposure and good asthma control.在血液中性粒细胞计数低、交通相关空气污染暴露少且哮喘控制良好的儿童哮喘患者中，鼻上皮细胞对白细胞介素-17A的反应性增加。
Clin Exp Allergy. 2022 Apr;52(4):569-573. doi: 10.1111/cea.14080. Epub 2021 Dec 27.

本文引用的文献

1
Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cells.香烟烟雾对人呼吸道上皮细胞中白细胞介素-13诱导的基因表达有不同影响。
Physiol Rep. 2017 Jul;5(13). doi: 10.14814/phy2.13347. Epub 2017 Jul 11.
2
The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition.随着时间的推移，DNA 甲基化与 Th2 途径遗传变异相互作用对哮喘风险和哮喘的时间转变的影响。
Clin Epigenetics. 2014 Apr 15;6(1):8. doi: 10.1186/1868-7083-6-8. eCollection 2014.
3
Diesel exhaust particle induction of IL-17A contributes to severe asthma.柴油机废气颗粒诱导白细胞介素-17A 导致严重哮喘。
J Allergy Clin Immunol. 2013 Nov;132(5):1194-1204.e2. doi: 10.1016/j.jaci.2013.06.048. Epub 2013 Sep 20.
4
The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years.遗传变异与白细胞介素-4 受体基因的 DNA 甲基化相互作用增加了 18 岁时哮喘的风险。
Clin Epigenetics. 2013 Jan 3;5(1):1. doi: 10.1186/1868-7083-5-1.
5
Interleukin-13 signaling and its role in asthma.白细胞介素-13 信号及其在哮喘中的作用。
World Allergy Organ J. 2011 Mar;4(3):54-64. doi: 10.1097/WOX.0b013e31821188e0.
6
Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation.产前二手烟促进 Th2 极化，损害杯状细胞分化和气道黏液形成。
J Immunol. 2011 Nov 1;187(9):4542-52. doi: 10.4049/jimmunol.1101567. Epub 2011 Sep 19.
7
Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease.白细胞介素 13 通路基因多态性与哮喘和慢性阻塞性肺疾病。
Allergy. 2010 Apr;65(4):474-81. doi: 10.1111/j.1398-9995.2009.02167.x. Epub 2009 Oct 1.
8
IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study.一项纵向研究表明，白细胞介素13基因多态性会改变儿童期接触烟草烟雾对持续性喘息和哮喘的影响。
Respir Res. 2008 Jan 10;9(1):2. doi: 10.1186/1465-9921-9-2.
9
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.白细胞介素-13对上皮细胞的直接作用会导致哮喘中的气道高反应性和黏液过度产生。
Nat Med. 2002 Aug;8(8):885-9. doi: 10.1038/nm734. Epub 2002 Jul 1.

Age and early maternal smoking contribute to epithelial cell IL-13 responsiveness in a pediatric asthma population.

作者信息

McAlees Jaclyn W, Baker Theresa, Kaur Davinder, McKnight Christopher, Lindsley Andrew, Strait Richard T, Zhang Xue, Biagini Myers Jocelyn M, Butsch Kovacic Melinda, Lewkowich Ian P

机构信息

The Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

The Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

出版信息

Allergy. 2019 Dec;74(12):2485-2487. doi: 10.1111/all.13876. Epub 2019 Jul 2.

DOI:10.1111/all.13876
PMID:31102477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6859185/
Abstract
摘要