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Increased nasal epithelial cell responsiveness to IL-17A in paediatric asthmatics with low blood neutrophil count, low traffic-related air pollution exposure and good asthma control.

作者信息

McAlees Jaclyn W, Baker Theresa, Houshel Lauren, McKnight Christopher, Lindsley Andrew, Strait Richard T, Zhang Xue, Cannata Angela, Biagini Jocelyn M, Butsch Kovacic Melinda, Lewkowich Ian P

机构信息

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

出版信息

Clin Exp Allergy. 2022 Apr;52(4):569-573. doi: 10.1111/cea.14080. Epub 2021 Dec 27.

DOI:10.1111/cea.14080
PMID:34908201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8976742/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90b3/8976742/3c0b354dd3eb/nihms-1764615-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90b3/8976742/3c0b354dd3eb/nihms-1764615-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90b3/8976742/3c0b354dd3eb/nihms-1764615-f0001.jpg

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Increased nasal epithelial cell responsiveness to IL-17A in paediatric asthmatics with low blood neutrophil count, low traffic-related air pollution exposure and good asthma control.在血液中性粒细胞计数低、交通相关空气污染暴露少且哮喘控制良好的儿童哮喘患者中，鼻上皮细胞对白细胞介素-17A的反应性增加。
Clin Exp Allergy. 2022 Apr;52(4):569-573. doi: 10.1111/cea.14080. Epub 2021 Dec 27.
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Diesel exhaust particles up-regulate interleukin-17A expression via ROS/NF-κB in airway epithelium.柴油机废气颗粒通过 ROS/NF-κB 在上皮细胞中上调白细胞介素-17A 的表达。
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Int Arch Allergy Immunol. 2010;151(1):8-16. doi: 10.1159/000232566. Epub 2009 Aug 6.
4
Cigarette smoking increases bronchial mucosal IL-17A expression in asthmatics, which acts in concert with environmental aeroallergens to engender neutrophilic inflammation.吸烟会增加哮喘患者支气管黏膜中白细胞介素-17A的表达，它与环境空气过敏原共同作用，引发嗜中性粒细胞炎症。
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Diesel exhaust particle induction of IL-17A contributes to severe asthma.柴油机废气颗粒诱导白细胞介素-17A 导致严重哮喘。
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Effects of photochemical air pollution and allergen exposure on upper respiratory tract inflammation in asthmatics.光化学空气污染和过敏原暴露对哮喘患者上呼吸道炎症的影响。
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Th-17 regulatory cytokines IL-21, IL-23, and IL-6 enhance neutrophil production of IL-17 cytokines during asthma.在哮喘期间，Th-17调节性细胞因子白细胞介素-21（IL-21）、白细胞介素-23（IL-23）和白细胞介素-6（IL-6）可增强中性粒细胞产生白细胞介素-17细胞因子。
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本文引用的文献

1
Age and early maternal smoking contribute to epithelial cell IL-13 responsiveness in a pediatric asthma population.年龄和母亲孕期早期吸烟会导致儿童哮喘人群中上皮细胞对白细胞介素-13产生反应。
Allergy. 2019 Dec;74(12):2485-2487. doi: 10.1111/all.13876. Epub 2019 Jul 2.
2
Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function.小儿重症哮喘中的上皮内中性粒细胞与更好的肺功能相关。
J Allergy Clin Immunol. 2017 Jun;139(6):1819-1829.e11. doi: 10.1016/j.jaci.2016.09.022. Epub 2016 Oct 13.
3
IL-17A enhances IL-13 activity by enhancing IL-13-induced signal transducer and activator of transcription 6 activation.
白细胞介素-17A通过增强白细胞介素-13诱导的信号转导和转录激活因子6的激活来增强白细胞介素-13的活性。
J Allergy Clin Immunol. 2017 Feb;139(2):462-471.e14. doi: 10.1016/j.jaci.2016.04.037. Epub 2016 Jun 11.
4
Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells.从儿童中培养原代鼻上皮细胞并重编程为诱导多能干细胞。
J Vis Exp. 2016 Mar 10(109):53814. doi: 10.3791/53814.
5
IL-17 in severe asthma. Where do we stand?白细胞介素-17 在重症哮喘中的作用。我们处于什么位置？
Am J Respir Crit Care Med. 2014 Nov 15;190(10):1094-101. doi: 10.1164/rccm.201405-0859PP.
6
Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma.支气管肺泡灌洗液中双阳性TH2/TH17细胞频率增加是重度哮喘患者群体的一个特征。
J Allergy Clin Immunol. 2014 Nov;134(5):1175-1186.e7. doi: 10.1016/j.jaci.2014.05.038. Epub 2014 Jul 18.
7
Diesel exhaust particle induction of IL-17A contributes to severe asthma.柴油机废气颗粒诱导白细胞介素-17A 导致严重哮喘。
J Allergy Clin Immunol. 2013 Nov;132(5):1194-1204.e2. doi: 10.1016/j.jaci.2013.06.048. Epub 2013 Sep 20.
8
Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma.补体介导的 IL-17A 轴调节是实验性变应性哮喘严重程度的主要遗传决定因素。
Nat Immunol. 2010 Oct;11(10):928-35. doi: 10.1038/ni.1926. Epub 2010 Aug 29.
9
Nasal epithelial cells as surrogates for bronchial epithelial cells in airway inflammation studies.在气道炎症研究中，鼻上皮细胞作为支气管上皮细胞的替代物。
Am J Respir Cell Mol Biol. 2008 Nov;39(5):560-8. doi: 10.1165/rcmb.2007-0325OC. Epub 2008 May 15.
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Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007.专家小组报告3（EPR-3）：哮喘诊断和管理指南——2007年总结报告
J Allergy Clin Immunol. 2007 Nov;120(5 Suppl):S94-138. doi: 10.1016/j.jaci.2007.09.043.