Department of Animal Science, Texas A&M University, 2471 TAMU, College Station, TX 77843, USA.
Vet Clin North Am Food Anim Pract. 2019 Jul;35(2):331-341. doi: 10.1016/j.cvfa.2019.02.004.
The concept of developmental programming was established using epidemiologic studies that investigated chronic illnesses in humans, such as coronary heart disease and hypertension. In livestock species, the impacts of developmental programming are important for production and welfare reasons and are used as research models for human and other animal species. Dams should be in adequate nutritional status to ensure optimal nutrient supply for fetal growth, including development of their immune system. Beef and dairy cows with insufficient nutrient intake during gestation produce calves with reduced immunity against diseases, such as scours, respiratory disease, and mastitis.
发育编程的概念是通过研究人类慢性疾病(如冠心病和高血压)的流行病学研究确立的。在畜牧物种中,发育编程的影响对于生产和福利原因很重要,并且被用作人类和其他动物物种的研究模型。母体应该处于足够的营养状态,以确保为胎儿生长提供最佳的营养供应,包括免疫系统的发育。在妊娠期间摄入营养不足的肉牛和奶牛所产的小牛对疾病(如腹泻、呼吸道疾病和乳腺炎)的免疫力降低。