Department of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, NDSU Department 7630, Fargo, ND 58108-6050, USA.
Advanced Imaging and Microscopy Core Lab, Department of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, NDSU Department 7630, Fargo, ND 58108-6050, USA.
Vet Clin North Am Food Anim Pract. 2019 Jul;35(2):229-247. doi: 10.1016/j.cvfa.2019.02.006.
Maternal stressors that affect fetal development result in "developmental programming," which is associated with increased risk of various chronic pathologic conditions in the offspring, including metabolic syndrome; growth abnormalities; and reproductive, immune, behavioral, or cognitive dysfunction that can persist throughout their lifetime and even across subsequent generations. Developmental programming thus can lead to poor health, reduced longevity, and reduced productivity. Current research aims to develop management and therapeutic strategies to optimize fetal growth and development and thereby overcome the negative consequences of developmental programming, leading to improved health, longevity, and productivity of offspring.
母体应激源会影响胎儿发育，导致“发育编程”，这与后代多种慢性病理状况的风险增加有关，包括代谢综合征；生长异常；以及生殖、免疫、行为或认知功能障碍，这些问题可能会持续一生，甚至会遗传到后代。因此，发育编程会导致健康状况不佳、寿命缩短和生产力降低。目前的研究旨在制定管理和治疗策略，以优化胎儿的生长和发育，从而克服发育编程的负面影响，提高后代的健康、寿命和生产力。
