一锅超声化学法合成 BiWO 纳米球，采用多层还原氧化石墨烯纳米片修饰电极作为快速电化学传感平台，用于生物样品中氧化应激生物标志物的高灵敏检测。
One-pot sonochemical synthesis of BiWO nanospheres with multilayer reduced graphene nanosheets modified electrode as rapid electrochemical sensing platform for high sensitive detection of oxidative stress biomarker in biological sample.
机构信息
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan.
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan.
出版信息
Ultrason Sonochem. 2019 Oct;57:233-241. doi: 10.1016/j.ultsonch.2019.04.011. Epub 2019 Apr 10.
4-Nitroquinoline N-oxide (4-NQO) is an important tumorigenic organic compound with high adverse effect in the human body. In this study, a novel Bismuth Tungstate nanospheres (BiWO) decorated reduced graphene oxide (BiWO/rGOS) nanocomposite have been designed through a sonochemical method. The as-synthesized BiWO/rGOS was characterized through the HRTEM, FESEM, XPS, EIS and XRD. Furthermore, the nanocomposite modified glassy carbon electrode (GCE) was developed for the determination of 4-NQO. The results showed that the BiWO/rGOS nanocomposite modified electrode exhibit valuable responses and excellent electrocatalytic activity. The fabricated sensor was facilitated the analysis of 4-NQO with a nanomolar detection limit (6.11 nM). Further, the as-synthesized BiWO/rGOS modified electrode has been applied to sensing of 4-NQO in human blood and urine samples with satisfactory recovery.
4-硝基喹啉 N-氧化物（4-NQO）是一种重要的致癌有机化合物，对人体有很高的不良影响。在本研究中，通过超声化学法设计了一种新型的钨酸铋纳米球（BiWO）修饰还原氧化石墨烯（BiWO/rGOS）纳米复合材料。通过 HRTEM、FESEM、XPS、EIS 和 XRD 对合成的 BiWO/rGOS 进行了表征。此外，还开发了纳米复合材料修饰的玻碳电极（GCE），用于测定 4-NQO。结果表明，BiWO/rGOS 纳米复合材料修饰电极具有有价值的响应和出色的电催化活性。所制备的传感器可用于分析纳摩尔检测限（6.11 nM）的 4-NQO。此外，所合成的 BiWO/rGOS 修饰电极已应用于人体血液和尿液样品中 4-NQO 的传感，具有令人满意的回收率。
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