应用肾包膜下测定法检测同种异体小鼠纤维肉瘤对热疗、化疗药物或联合治疗的敏感性。

Subrenal capsule assay applied to examine the sensitivity of allogenic mouse fibrosarcoma to hyperthermia, chemotherapeutic drugs or combined treatment.

作者信息

Sato S, Ootsuyama A, Hamada M, Tanooka H

出版信息

Int J Hyperthermia. 1987 Mar-Apr;3(2):177-82. doi: 10.3109/02656738709140385.

Abstract

The thermosensitivity and chemosensitivity of fibrosarcomas of C3H/He mouse were investigated using the subrenal capsule assay with female ICR mice as host. Five typical chemotherapeutic drugs (mitomycin C, adriamycin, 5-fluorouracil, cis-DDplatinum and cyclophosphamide) tested were effective in suppressing tumour growth. Total-body hyperthermia given at 41.5 degrees C for 30 min twice during the 6-day period exerted little effect. However, an interactive effect was found with the combination of hyperthermia and mitomycin C. The combination of hyperthermia with other drugs failed to exhibit an interactive effect, since the effects of the drugs alone were considerable. The potential clinical applicability of this test is discussed.

摘要

以雌性ICR小鼠为宿主，采用肾包膜下接种法研究了C3H/He小鼠纤维肉瘤的热敏感性和化学敏感性。所测试的五种典型化疗药物（丝裂霉素C、阿霉素、5-氟尿嘧啶、顺铂和环磷酰胺）均能有效抑制肿瘤生长。在6天内，41.5℃全身热疗30分钟，进行两次，效果甚微。然而，发现热疗与丝裂霉素C联合使用有交互作用。热疗与其他药物联合使用未显示出交互作用，因为单独使用这些药物的效果就相当可观。讨论了该试验潜在的临床适用性。