人参皂苷 Rg2 对 PTSD 动物模型的抗焦虑样作用。
The anxiolytic-like effects of ginsenoside Rg2 on an animal model of PTSD.
机构信息
Shunde Hospital, Southern Medical University, Foshan, 528308, P.R. China; Traditional Chinese Medicine School, Southern Medical University, Guangzhou, 510515, P.R. China; Shunde Hospital, Guangzhou University of Chinese Medicine, Foshan, 528333,P.R. China.
Shunde Hospital, Southern Medical University, Foshan, 528308, P.R. China.
出版信息
Psychiatry Res. 2019 Sep;279:130-137. doi: 10.1016/j.psychres.2018.12.034. Epub 2018 Dec 6.
Post traumatic stress disorder (PTSD) is one of the mental illness. The antidepressant-like properties of ginsenoside Rg2 (GRg2) have been shown, while little is known about its anti-PTSD-like effects. In the present study, the PTSD-associated behavioral deficits in rats were induced following exposure to single prolonged stress (SPS). The results showed that the decreased time and entries in the open arms in elevated plus maze test (EPMT) and increased freezing duration in contextual fear paradigm (CFP) were reversed by GRg2 (10 and 20 mg/kg) without affecting the locomotor activity. In addition, GRg2 (10 and 20 mg/kg) could block the decreased levels of progesterone, allopregnanolone, serotonin (5-HT), 5-Hydroxyindoleacetic acid (5-HIAA), corticotropin releasing hormone (CRH), corticosterone (Cort) and adrenocorticotropic hormone (ACTH) in the brain or serum. In summary, GRg2 alleviated the PTSD-associated behavioral deficits with biosynthesis of neurosteroids, normalization of serotonergic system and HPA axis dysfunction.
创伤后应激障碍（PTSD）是一种精神疾病。已显示人参皂苷 Rg2（GRg2）具有抗抑郁作用，但其抗 PTSD 样作用知之甚少。在本研究中，通过单次延长应激（SPS）诱导大鼠 PTSD 相关行为缺陷。结果表明，GRg2（10 和 20mg/kg）可逆转高架十字迷宫测试（EPMT）中进入开放臂的时间和次数减少以及情境恐惧范式（CFP）中冻结时间延长，而不影响运动活性。此外，GRg2（10 和 20mg/kg）可阻断大脑或血清中孕激素、别孕烯醇酮、5-羟色胺（5-HT）、5-羟吲哚乙酸（5-HIAA）、促肾上腺皮质激素释放激素（CRH）、皮质酮（Cort）和促肾上腺皮质激素（ACTH）水平降低。总之，GRg2 通过神经甾体的生物合成、5-羟色胺能系统的正常化和 HPA 轴功能障碍缓解了 PTSD 相关的行为缺陷。
Zotero 插件