Pharmaceutical Department of the First Affiliated Hospital of Guangdong Pharmaceutical University, Clinical Pharmacy Department of Guangdong Pharmaceutical University, Guangzhou, 510080, People's Republic of China.
Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China.
Metab Brain Dis. 2018 Aug;33(4):1175-1185. doi: 10.1007/s11011-018-0216-4. Epub 2018 Apr 10.
Post-traumatic stress disorder (PTSD) is the serious psychiatric disorder. Paeoniflorin (PF) produces the antidepressant-like properties. However, few studies are concerned about its anti-PTSD-like effects and mechanisms. To investigate these, the single prolonged stress (SPS) model was utilized. PTSD-like behavioral deficits in rats after exposure to SPS were improved by PF (10 and 20 mg/kg, i.p.), evidenced by blocking increased freezing time in contextual fear paradigm (CFP) and increased time and entries in open arms in elevated plus maze (EPM) test without affecting the locomotor activity in open field (OF) test. We also found that increased levels of corticosterone (Cort), corticotropin releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) after exposure to SPS were reversed by PF (10 and 20 mg/kg, i.p.) in serum, respectively. Moreover, the decreased levels of serotonin (5-HT) and 5-Hydroxyindoleacetic acid (5-HIAA) in prefrontal cortex and hippocampus were reversed by PF (10 and 20 mg/kg, i.p.), respectively. In summary, the anti-PTSD-like activities of PF were associated with the modulation of HPA axis and 5-HT system activation.
创伤后应激障碍（PTSD）是一种严重的精神障碍。芍药苷（PF）具有抗抑郁作用。然而，很少有研究关注其抗 PTSD 样作用及其机制。为了研究这些，我们利用了单次延长应激（SPS）模型。PF（10 和 20mg/kg，ip）可改善 SPS 暴露后大鼠的 PTSD 样行为缺陷，表现为阻断情景恐惧范式（CFP）中冻结时间的增加和高架十字迷宫（EPM）测试中开放臂时间和进入次数的增加，而不影响旷场（OF）测试中的运动活性。我们还发现，PF（10 和 20mg/kg，ip）可分别逆转 SPS 后血清中皮质酮（Cort）、促肾上腺皮质激素释放激素（CRH）和促肾上腺皮质激素（ACTH）水平的升高。此外，PF（10 和 20mg/kg，ip）还可逆转前额叶皮层和海马中 5-羟色胺（5-HT）和 5-羟吲哚乙酸（5-HIAA）水平的降低。综上所述，PF 的抗 PTSD 样活性与 HPA 轴和 5-HT 系统激活的调节有关。
