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美洲儿童虫媒病毒感染的神经表现。

Neurological manifestations of pediatric arboviral infections in the Americas.

机构信息

Professor _Departamento de Pediatria, Universidade Federal de Minas Gerais-Minas Gerais, Brazil; Hospital Infantil João Paulo II, FHEMIG, Minas Gerais, Brazil.

Professor _Laboratório de Vírus, Departamento de Microbiologia, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.

出版信息

J Clin Virol. 2019 Jul;116:49-57. doi: 10.1016/j.jcv.2019.04.006. Epub 2019 May 8.

Abstract

Dengue, Zika, Chikungunya and yellow fever viruses are arboviruses transmitted by the mosquito Aedes aegypti. These viruses exhibit marked neurotropism but have rarely been studied. Here, we conduct an integrative review of the neurological manifestations caused by these arboviruses in the pediatric population. Data on patients under 18 years of age were extracted from literature databases. The most frequently reported neurological manifestations were encephalitis, meningitis, seizures, hypotonia, paresis, and behavioral changes. This review highlights the importance of accurately diagnosing these arboviral infections in children and adolescents with neurological manifestations.

摘要

登革热、 Zika、基孔肯雅热和黄热病病毒都是由埃及伊蚊传播的虫媒病毒。这些病毒具有明显的嗜神经性,但很少被研究。在这里,我们对儿科人群中这些虫媒病毒引起的神经系统表现进行了综合回顾。从文献数据库中提取了 18 岁以下患者的数据。报道最多的神经系统表现是脑炎、脑膜炎、癫痫发作、张力减退、瘫痪和行为改变。本综述强调了准确诊断儿童和青少年出现神经系统表现的这些虫媒病毒感染的重要性。

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