Saint Elisabeth Hospital, Willemstad, Curaçao.
Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
BMC Infect Dis. 2021 Feb 16;21(1):179. doi: 10.1186/s12879-021-05876-4.
Perinatally chikungunya infected neonates have been reported to have high rates of post-infection neurologic sequelae, mainly cognitive problems. In older children and adults chikungunya does not appear to have sequelae, but data on postnatally infected infants are lacking.
We performed a prospective, non-controlled, observational study of infants infected before the age of 6 months with a severe chikungunya infection during the 2014-2015 epidemic in Curaçao, Dutch Antilles. Two years post-infection cognitive and motor - (BSID-III) and social emotional assessments (ITSEA) were performed.
Of twenty-two infected infants, two died and two were lost to follow up. Eighteen children were seen at follow-up and included in the current study. Of these, 13 (72%) had abnormal scores on the BSID-III (cognitive/motor) or ITSEA.
In the first study aimed at postnatally infected infants, using an uncontrolled design, we observed a very high percentage of developmental problems. Further studies are needed to assess causality, however until these data are available preventive measure during outbreaks should also include young infants. Those that have been infected in early infancy should receive follow up.
有报道称，围产期感染基孔肯雅热的新生儿在感染后有很高的神经系统后遗症发生率，主要是认知问题。在较大的儿童和成年人中，基孔肯雅热似乎没有后遗症，但关于感染后婴儿的数据尚缺乏。
我们对 2014-2015 年在荷属安的列斯库拉索岛流行期间感染年龄小于 6 个月的严重基孔肯雅热的婴儿进行了一项前瞻性、非对照、观察性研究。在感染后 2 年进行了认知和运动评估（BSID-III）和社会情感评估（ITSEA）。
在 22 例感染婴儿中，2 例死亡，2 例失访。18 例患儿在随访时接受了检查，并纳入了本研究。其中，13 例（72%）BSID-III（认知/运动）或 ITSEA 评分异常。
在第一项旨在研究感染后婴儿的研究中，我们使用非对照设计观察到非常高比例的发育问题。需要进一步研究来评估因果关系，但是在这些数据可用之前，在疫情爆发期间也应包括幼儿在内采取预防措施。那些在婴儿早期感染的婴儿应接受随访。
