Megalla S E, Nassar A Y, Gohar M A
J Basic Microbiol. 1987;27(1):29-33. doi: 10.1002/jobm.3620270105.
Addition of cooper-monovalent-nicotinic acid complex to a synthetic medium specific for kojic acid production by Aspergillus flavus enhanced the production by about 47%. The substance is proposed to act via a biochemical utilization of the copper(I)-B3 complex in a manner similar to that of the naturally utilized nicotinic acid. NAD and NADP like carriers with higher reactivity have been predicted. According to this prediction the biosynthetic route of kojic acid has been interpreted on the basis of a model proposed by Bajpai et al. (1981). In this model the enzymes participating are dependent on NAD and NADP (glucose dehydrogenase and gluconate dehydrogenase) as well as on other reduction processes.
向黄曲霉产曲酸的特定合成培养基中添加铜一价烟酸复合物可使产量提高约47%。有人提出该物质通过铜（I）-B3复合物的生化利用方式起作用，类似于天然利用的烟酸。已经预测了具有更高反应活性的NAD和NADP样载体。根据这一预测，基于Bajpai等人（1981年）提出的模型解释了曲酸的生物合成途径。在该模型中，参与的酶依赖于NAD和NADP（葡萄糖脱氢酶和葡萄糖酸脱氢酶）以及其他还原过程。
