Grün R, Günther C, Kaffarnik H
Klin Wochenschr. 1987 May 4;65(9):411-8. doi: 10.1007/BF01715763.
The hormonal status of men with cirrhosis of the liver has been investigated in numerous studies. Little, however, is known about changes of sexual hormones in women afflicted by this disorder. In a study of 31 postmenopausal women (mean age 63 +/- 8 years) suffering from cirrhosis of various etiology (alcoholic, n = 8; posthepatitic B, n = 1; PBC, n = 5; cryptogenetic, n = 17) the blood levels of estradiol (E2), estrone (E1), androstenedione (A), testosterone (T) and basal and stimulated values of gonadotropins are reported and compared with the data obtained in an age-matched control group (n = 9). In cirrhosis a significant increase of the median E2 (28 vs 12 pg/ml, P less than 0.01) was found, whereas the changes of the blood levels of E1 (88 vs 76 pg/ml), A (63 vs 111 ng/dl), and T (0.30 vs 0.15 ng/ml) did not attain statistical significance in comparison to controls. Within the study group, however, a significant positive correlation with the degree of decompensation of cirrhosis (Childscore A-C) was observed for the steroid hormones measured. Thus, in subgroup C the hormone levels are higher than physiologically expected for postmenopausal women. On the other hand the median FSH (32 vs 48 mU/ml, P less than 0.05) is significantly lower in cirrhosis compared to controls with a trend to decreased values of LH. Very low levels of LH and FSH are found in decompensated cirrhosis. The decrease of LH and FSH can partly be explained by the rise of peripheral hormones (i.e. E2, E1, and in some cases T and A).(ABSTRACT TRUNCATED AT 250 WORDS)
众多研究对患有肝硬化的男性的激素状况进行了调查。然而，对于患有这种疾病的女性性激素变化却知之甚少。在一项针对31名绝经后女性（平均年龄63±8岁）的研究中，她们患有各种病因的肝硬化（酒精性，n = 8；乙型肝炎后，n = 1；原发性胆汁性肝硬化，n = 5；隐源性，n = 17），报告了雌二醇（E2）、雌酮（E1）、雄烯二酮（A）、睾酮（T）的血液水平以及促性腺激素的基础值和刺激值，并与年龄匹配的对照组（n = 9）获得的数据进行了比较。在肝硬化患者中，发现E2中位数显著升高（28 vs 12 pg/ml，P<0.01），而与对照组相比，E1（88 vs 76 pg/ml）、A（63 vs 111 ng/dl）和T（0.30 vs 0.15 ng/ml）的血液水平变化未达到统计学显著性。然而，在研究组内，所测类固醇激素与肝硬化失代偿程度（Child评分A - C）呈显著正相关。因此，在C亚组中，激素水平高于绝经后女性的生理预期。另一方面，与对照组相比，肝硬化患者的FSH中位数显著降低（32 vs 48 mU/ml，P<0.05），LH值有下降趋势。在失代偿性肝硬化中发现LH和FSH水平极低。LH和FSH的降低部分可由外周激素（即E2、E1，在某些情况下还有T和A）的升高来解释。（摘要截短于250字）
