Klinga K, von Holst T, Runnebaum B
Eur J Obstet Gynecol Reprod Biol. 1983 Jun;15(2):103-12. doi: 10.1016/0028-2243(83)90178-8.
To investigate the influence of obesity on hormonal parameters in 186 apparently healthy women and in 176 women suffering from severe obesity the serum concentrations of FSH, LH, estrone (E1), estradiol (E2), androstenedione (A) and testosterone (T) were determined radioimmunologically. The climacteric onset of increased FSH production is 4 yr earlier (P less than 0.001) in obese than in normal women. Parallel to the rise of FSH there is a significantly premature decrease of the E1 and E2 concentrations in obese women. The typical elevation of the LH was found similar and not significantly different in the two collectives. The mean A levels are significantly lower (P less than 0.01) in obese than in normal women in all age groups. The T concentrations do not depend on the age of the women during the investigated period (41 to 60 yr) and are significantly higher (P less than 0.001) in the obese than in the normal women. There is a significant (P less than 0.001) correlation between the concentrations of A and E1 both in the obese and the normal women. An increased conversion of androgens to estrogens by adipose tissue is not revealed by the peripheral serum concentrations. Our data clearly demonstrate that in obese women the onset of ovarian insufficiency is significantly earlier than in normal women.
为研究肥胖对186名貌似健康女性及176名重度肥胖女性激素参数的影响，采用放射免疫法测定了血清促卵泡生成素（FSH）、促黄体生成素（LH）、雌酮（E1）、雌二醇（E2）、雄烯二酮（A）和睾酮（T）的浓度。肥胖女性中FSH分泌增加的更年期起始时间比正常女性早4年（P<0.001）。与FSH升高同时，肥胖女性的E1和E2浓度显著过早下降。在两个群体中，LH的典型升高情况相似且无显著差异。在所有年龄组中，肥胖女性的平均A水平均显著低于正常女性（P<0.01）。在研究期间（41至60岁），T浓度不取决于女性年龄，肥胖女性的T浓度显著高于正常女性（P<0.001）。肥胖女性和正常女性的A与E1浓度之间均存在显著相关性（P<0.001）。外周血清浓度未显示脂肪组织将雄激素转化为雌激素的作用增强。我们的数据清楚地表明，肥胖女性卵巢功能不全的起始时间明显早于正常女性。
