Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
Division for Mental Health and Addiction, Vestfold Hospital Trust, Tønsberg, Norway.
Aging Ment Health. 2020 Sep;24(9):1394-1401. doi: 10.1080/13607863.2019.1617245. Epub 2019 May 20.
To compare quality of life (QOL) of family carers of persons with young- (YOD) to late-onset dementia (LOD). This was a cross-sectional comparison of 88 carers of persons with YOD and 100 carers of persons with LOD. The Quality of Life - Alzheimer's Disease questionnaire (QOL-AD) was used to measure QOL of both carers and persons with dementia. Depressive symptoms were measured by the Geriatric Depression Scale (GDS) for carers and the Cornell Scale for Depression in Dementia for persons with dementia. Care burden was measured by the Relatives' Stress Scale. Activities of Daily Living (ADL) of the persons with dementia were assessed using the total score from the Lawton & Brody Instrumental-ADL scale and the Physical Self-Maintenance Scale. Multiple linear regression models with interactions between covariates and group (YOD versus LOD) were estimated. The QOL-AD scores of YOD-carers were significantly poorer compared to LOD-carers (mean difference 2.5 (95% CI 0.7; 4.3), = 0.006). Poorer QOL of carers was associated with more depressive symptoms (mean QOL-AD change -0.5 (-0.6; -0.3), < 0.001), but with no difference between the two groups. In contrast to LOD, QOL of carers of people with YOD was also significantly associated with symptom duration ( = 0.002), depressive symptoms of the persons with dementia ( = 0.030), ADL ( = 0.001), and carer burden ( = 0.002). YOD-carers reported significantly poorer QOL compared to LOD-carers. QOL was significantly associated with depressive symptoms in carers of both groups.
比较中青年发病（YOD）与晚发痴呆（LOD）患者家属的生活质量（QOL）。方法：这是一项 88 名 YOD 患者家属和 100 名 LOD 患者家属的横断面比较研究。使用生活质量 - 阿尔茨海默病问卷（QOL-AD）来衡量两组照顾者和痴呆患者的生活质量。照顾者的抑郁症状用老年抑郁量表（GDS）和痴呆患者的康奈尔抑郁量表进行评估。使用亲属应激量表来衡量照顾者的负担。使用 Lawton 和 Brody 工具性日常生活活动量表的总分和身体自我维护量表来评估痴呆患者的日常生活活动能力（ADL）。采用多元线性回归模型，并对协变量和组（YOD 与 LOD）之间的交互作用进行了估计。与 LOD 患者家属相比，YOD 患者家属的 QOL-AD 评分明显更差（平均差异 2.5（95%CI 0.7；4.3）， = 0.006）。照顾者的 QOL 越差，抑郁症状越明显（QOL-AD 变化平均差异 -0.5（-0.6；-0.3）， < 0.001），但两组之间没有差异。与 LOD 不同，YOD 患者家属的 QOL 还与症状持续时间（ = 0.002）、痴呆患者的抑郁症状（ = 0.030）、ADL（ = 0.001）和照顾者负担（ = 0.002）显著相关。与 LOD 患者家属相比，YOD 患者家属的 QOL 明显更差。两组照顾者的 QOL 均与抑郁症状显著相关。
