Borroni Barbara, Libri Ilenia, Rota Matteo, Binetti Giuliano, Benussi Luisa, Ghidoni Roberta, Cotelli Maria Sofia, Fostinelli Silvia, Guerini Fabio, Boffelli Stefano, Magni Eugenio, Pengo Marta, Gennuso Michele, Bianchi Marta, Cossu Beatrice, Palomba Vincenzo, Crucitti Andrea, Bianchetti Angelo, Logroscino Giancarlo, Padovani Alessandro
Department of Clinical and Experimental Sciences University of Brescia Brescia Italy.
Department of Continuity of Care and Frialty ASST Spedali Civili Brescia Brescia Italy.
Alzheimers Dement (Amst). 2024 Feb 29;16(1):e12544. doi: 10.1002/dad2.12544. eCollection 2024 Jan-Mar.
The goal of the present work was to assess the incidence of dementia with onset before the age of 65 years (i.e., young-onset dementia [YOD]) and define the frequencies of young-onset Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and dementia with Lewy bodies (DLB) in the general population.
The study was conducted from January 1, 2019 to December 31, 2019 in Brescia province (population: 1,268,455). During the study period, all new YOD cases (incident YOD) were counted, and all patients' records reviewed. The incidence was standardized to the Italian general population in 2019.
A total of 29 YOD patients were diagnosed. The age-sex standardized incidence rate was 4.58 (95% confidence interval, 3.07-6.58) per 100,000 person-years. No difference in incidence rate between YOD due to AD or FTLD ( = 0.83) and between sexes ( = 0.81) was observed. YOD incidence increased with age, reaching its peak after 60 years.
Presenting neurodegenerative YOD phenotypes encompasses both AD and FTLD. Improved knowledge on YOD epidemiology is essential to adequately plan and organize health services.
本研究的目的是评估65岁之前发病的痴呆症（即早发性痴呆症[YOD]）的发病率，并确定普通人群中早发性阿尔茨海默病（AD）、额颞叶变性（FTLD）和路易体痴呆（DLB）的发病频率。
该研究于2019年1月1日至2019年12月31日在布雷西亚省进行（人口：1,268,455）。在研究期间，统计所有新的YOD病例（新发YOD），并查阅所有患者的记录。发病率根据2019年意大利普通人群进行标准化。
共诊断出29例YOD患者。年龄-性别标准化发病率为每10万人年4.58（95%置信区间，3.07 - 6.58）。未观察到因AD或FTLD导致的YOD之间的发病率差异（P = 0.83）以及性别之间的发病率差异（P = 0.81）。YOD发病率随年龄增加，在60岁后达到峰值。
呈现的神经退行性YOD表型包括AD和FTLD。提高对YOD流行病学的认识对于充分规划和组织卫生服务至关重要。
