a Department of Chemical and Food Engineering, Technological Center , Federal University of Santa Catarina , Florianópolis , Brazil.
b Department of Textile Engineering, Blumenau campus , Federal University of Santa Catarina , Blumenau , Brazil.
J Biomater Sci Polym Ed. 2019 Aug;30(12):1026-1049. doi: 10.1080/09205063.2019.1620592. Epub 2019 Jun 2.
Scaffold-type biomaterials are crucial for application in tissue engineering. Among them, the use of a nonwoven scaffold has grown in recent years and has been widely investigated for the regeneration of different types of tissues. Several polymers, whether they are synthetic, biopolymers or both, have been used to produce a scaffold that can mimic the natural tissue to which it will be applied to. The scaffolds used in tissue engineering must be biocompatible and allow cell adhesion and proliferation to be applied in tissue engineering. In addition, the scaffolds should maintain the mechanical properties and architecture of the desired tissue. Nonwoven fabrics have produced good results and are more extensively applied for the regeneration of cartilage, epithelial and bone tissues. Recent advances in tissue engineering have shown promising results, however, no ideal material or standardization parameters and characteristics of the materials were obtained. The present review provides an overview of the application of nonwoven scaffolds, including the main results obtained regarding the properties of the biomaterials and their applications and , focusing on the cartilaginous, the epithelium, and bone tissue regeneration.
支架型生物材料在组织工程应用中至关重要。其中,近年来无纺支架的应用日益增多,并广泛研究用于不同类型组织的再生。已经使用了几种聚合物,无论是合成的、生物聚合物还是两者的组合,来生产一种支架,这种支架可以模拟将其应用于的天然组织。用于组织工程的支架必须具有生物相容性,并允许细胞黏附和增殖,以应用于组织工程中。此外,支架应保持所需组织的机械性能和结构。无纺织物已取得良好效果,更广泛地应用于软骨、上皮和骨组织的再生。组织工程的最新进展显示出有希望的结果,然而,并未获得理想的材料或标准化参数以及材料的特性。本综述概述了无纺支架的应用,包括关于生物材料的性能及其应用的主要结果,重点关注软骨、上皮和骨组织的再生。